Regulation of dopamine D3 receptor in the striatal regions and substantia nigra in diffuse Lewy body disease
Highlights • Quantitative autoradiography of dopamine D1 , D2 , D3 receptors, VMAT2 and DAT. • Dopamine D2 and D3 receptor densities were measured using a novel procedure. • In Lewy body disease, D3 receptors were upregulated in the striatum.
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| Veröffentlicht in: | Neuroscience 2013-09, Vol.248, p.112-126 |
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| container_end_page | 126 |
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| container_title | Neuroscience |
| container_volume | 248 |
| creator | Sun, J Cairns, N.J Perlmutter, J.S Mach, R.H Xu, J |
| description | Highlights • Quantitative autoradiography of dopamine D1 , D2 , D3 receptors, VMAT2 and DAT. • Dopamine D2 and D3 receptor densities were measured using a novel procedure. • In Lewy body disease, D3 receptors were upregulated in the striatum. |
| doi_str_mv | 10.1016/j.neuroscience.2013.05.048 |
| format | Article |
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| ispartof | Neuroscience, 2013-09, Vol.248, p.112-126 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Aged Aged, 80 and over Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases diffuse Lewy body disease Dopamine Plasma Membrane Transport Proteins - metabolism dopamine receptors Female Humans Lewy Body Disease - diagnostic imaging Lewy Body Disease - metabolism Male Medical sciences Neostriatum - diagnostic imaging Neostriatum - metabolism Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Parkinson disease Piperazines quantitative autoradiography Raclopride Radionuclide Imaging Receptors, Dopamine D2 - metabolism Receptors, Dopamine D3 - metabolism Substantia Nigra - diagnostic imaging Substantia Nigra - metabolism Vesicular Monoamine Transport Proteins - metabolism |
| title | Regulation of dopamine D3 receptor in the striatal regions and substantia nigra in diffuse Lewy body disease |
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