Regulation of dopamine D3 receptor in the striatal regions and substantia nigra in diffuse Lewy body disease

Highlights • Quantitative autoradiography of dopamine D1 , D2 , D3 receptors, VMAT2 and DAT. • Dopamine D2 and D3 receptor densities were measured using a novel procedure. • In Lewy body disease, D3 receptors were upregulated in the striatum.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2013-09, Vol.248, p.112-126
Hauptverfasser:	Sun, J, Cairns, N.J, Perlmutter, J.S, Mach, R.H, Xu, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases diffuse Lewy body disease Dopamine Plasma Membrane Transport Proteins - metabolism dopamine receptors Female Humans Lewy Body Disease - diagnostic imaging Lewy Body Disease - metabolism Male Medical sciences Neostriatum - diagnostic imaging Neostriatum - metabolism Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Parkinson disease Piperazines quantitative autoradiography Raclopride Radionuclide Imaging Receptors, Dopamine D2 - metabolism Receptors, Dopamine D3 - metabolism Substantia Nigra - diagnostic imaging Substantia Nigra - metabolism Vesicular Monoamine Transport Proteins - metabolism
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Beschreibung
Zusammenfassung:	Highlights • Quantitative autoradiography of dopamine D1 , D2 , D3 receptors, VMAT2 and DAT. • Dopamine D2 and D3 receptor densities were measured using a novel procedure. • In Lewy body disease, D3 receptors were upregulated in the striatum.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.05.048