Post‐Genome‐Wide Association Study Challenges for Lipid Traits: Describing Age as a Modifier of Gene‐Lipid Associations in the Population Architecture Using Genomics and Epidemiology (PAGE) Study

Post‐Genome‐Wide Association Study Challenges for Lipid Traits: Describing Age as a Modifier of Gene‐Lipid Associations in the Population Architecture Using Genomics and Epidemiology (PAGE) Study

Summary Numerous common genetic variants that influence plasma high‐density lipoprotein cholesterol, low‐density lipoprotein cholesterol (LDL‐C), and triglyceride distributions have been identified via genome‐wide association studies (GWAS). However, whether or not these associations are age‐depende...

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Veröffentlicht in:Annals of human genetics 2013-09, Vol.77 (5), p.416-425
Hauptverfasser: Dumitrescu, Logan, Carty, Cara L., Franceschini, Nora, Hindorff, Lucia A., Cole, Shelley A., Bůžková, Petra, Schumacher, Fredrick R., Eaton, Charles B., Goodloe, Robert J., Duggan, David J., Haessler, Jeff, Cochran, Barbara, Henderson, Brian E., Cheng, Iona, Johnson, Karen C., Carlson, Chris S., Love, Shelly‐Ann, Brown‐Gentry, Kristin, Nato, Alejandro Q., Quibrera, Miguel, Anderson, Garnet, Shohet, Ralph V., Ambite, José Luis, Wilkens, Lynne R., Marchand, Loïc Le, Haiman, Christopher A., Buyske, Steven, Kooperberg, Charles, North, Kari E., Fornage, Myriam, Crawford, Dana C.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Age
Aged
Delta-5 Fatty Acid Desaturase
Female
genetic association
Genetic Association Studies
Genome-Wide Association Study
Genomes
Humans
Lipids
Lipids - blood
Low density lipoprotein
Male
Middle Aged
modifier
PAGE
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Quantitative Trait, Heritable
Risk Factors
White People - genetics
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Zusammenfassung:Summary Numerous common genetic variants that influence plasma high‐density lipoprotein cholesterol, low‐density lipoprotein cholesterol (LDL‐C), and triglyceride distributions have been identified via genome‐wide association studies (GWAS). However, whether or not these associations are age‐dependent has largely been overlooked. We conducted an association study and meta‐analysis in more than 22,000 European Americans between 49 previously identified GWAS variants and the three lipid traits, stratified by age (males:
ISSN:0003-4800
1469-1809
1469-1809
DOI:10.1111/ahg.12027