Mechanisms of peptide repertoire selection by HLA-DM

Highlights • HLA-DM stabilizes empty HLA-DR1 through major conformational changes of the groove. • These conformational changes enable a rapid peptide selection process. • HLA-DO acts as a substrate mimic that blocks HLA-DM activity. • HLA-DO lacks key residues required for stable peptide binding....

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Veröffentlicht in:	Trends in immunology 2013-10, Vol.34 (10), p.495-501
Hauptverfasser:	Pos, Wouter, Sethi, Dhruv K, Wucherpfennig, Kai W
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antigen presentation Antigen Presentation - immunology Autoimmune diseases crystal structure Diabetes dissociation Editing Histocompatibility Antigens Class II - chemistry Histocompatibility Antigens Class II - immunology HLA-D Antigens - chemistry HLA-D Antigens - immunology Humans Ligands Lymphocytes MHC class II molecules Mutation Pathogenesis Peptides Peptides - immunology Protein Binding - immunology Proteins sequence homology
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Beschreibung
Zusammenfassung:	Highlights • HLA-DM stabilizes empty HLA-DR1 through major conformational changes of the groove. • These conformational changes enable a rapid peptide selection process. • HLA-DO acts as a substrate mimic that blocks HLA-DM activity. • HLA-DO lacks key residues required for stable peptide binding.
ISSN:	1471-4906 1471-4981
DOI:	10.1016/j.it.2013.06.002