DNA Aptamer-Mediated Cell Targeting

An apt modification: A simple and effective way to modify the cell surface with target‐specific ligands, such as DNA aptamers, while minimizing the effects on the modified cells has been developed. After incubating with lipo–aptamer probes, immune cells (red, see scheme) recognize and kill cancer ce...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Angewandte Chemie International Edition 2013-01, Vol.52 (5), p.1472-1476
Hauptverfasser:	Xiong, Xiangling, Liu, Haipeng, Zhao, Zilong, Altman, Meghan B., Lopez-Colon, Dalia, Yang, Chaoyong James, Chang, Lung-Ji, Liu, Chen, Tan, Weihong
Format:	Artikel
Sprache:	eng
Schlagworte:	aptamers Aptamers, Nucleotide - chemistry Cancer Cell Line, Tumor cell modification cell recognition cell-based immunotherapy Deoxyribonucleic acid DNA DNA Probes - chemistry DNA Probes - metabolism Humans K562 Cells Ligands Lipids - chemistry Recognition T-Lymphocytes, Cytotoxic - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	An apt modification: A simple and effective way to modify the cell surface with target‐specific ligands, such as DNA aptamers, while minimizing the effects on the modified cells has been developed. After incubating with lipo–aptamer probes, immune cells (red, see scheme) recognize and kill cancer cells (blue) in the cell mixture.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201207063