Low oxygen stimulates the immune system

Changes in tissue oxygen levels trigger molecular signaling pathways that regulate cellular proliferation and differentiation in multiple cell types. The functional role of oxygen signaling in the immune system is not well understood. Rama and colleagues demonstrate that hypoxia induces dendritic-ce...

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Veröffentlicht in:	Kidney international 2008-04, Vol.73 (7), p.797-799
Hauptverfasser:	Maltzman, J.S., Haase, V.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Basic Helix-Loop-Helix Transcription Factors - physiology Cell Hypoxia - physiology Dendritic Cells - physiology Hypoxia-Inducible Factor 1 - physiology Immune System - physiology Kidney Diseases - etiology
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Beschreibung
Zusammenfassung:	Changes in tissue oxygen levels trigger molecular signaling pathways that regulate cellular proliferation and differentiation in multiple cell types. The functional role of oxygen signaling in the immune system is not well understood. Rama and colleagues demonstrate that hypoxia induces dendritic-cell maturation; thus they provide a novel mechanistic link between hypoxia/ischemia and the activation of the immune system in the kidney.
ISSN:	0085-2538 1523-1755
DOI:	10.1038/ki.2008.15