Calcium inhibits promotion by hot dog of 1,2‐dimethylhydrazine‐induced mucin‐depleted foci in rat colon
Epidemiology suggests that processed meat is associated with colorectal cancer risk, but few experimental studies support this association. We have shown that a model of cured meat made in a pilot workshop promotes preneoplastic lesions, mucin‐depleted foci (MDF) in the colon of rats. This study had...
Gespeichert in:
| Veröffentlicht in: | International journal of cancer 2013-12, Vol.133 (11), p.2533-2541 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2541 |
|---|---|
| container_issue | 11 |
| container_start_page | 2533 |
| container_title | International journal of cancer |
| container_volume | 133 |
| creator | Santarelli, Raphaelle L. Naud, Nathalie Taché, Sylviane Guéraud, Françoise Vendeuvre, Jean‐Luc Zhou, Lin Anwar, Muhammad M. Mirvish, Sidney S. Corpet, Denis E. Pierre, Fabrice H.F. |
| description | Epidemiology suggests that processed meat is associated with colorectal cancer risk, but few experimental studies support this association. We have shown that a model of cured meat made in a pilot workshop promotes preneoplastic lesions, mucin‐depleted foci (MDF) in the colon of rats. This study had two aims: to check if real store‐bought processed meats also promote MDF, and to test if calcium carbonate, which suppresses heme‐induced promotion, can suppress promotion by processed meat. A 14‐day study was done to test the effect of nine purchased cured meats on fecal and urinary biomarkers associated with heme‐induced carcinogenesis promotion. Fecal water from rats given hot dog or fermented raw dry sausage was particularly cytotoxic. These two cured meats were thus given to rats pretreated with 1,2‐dimethylhydrazine, to evaluate their effect on colorectal carcinogenesis. After a 100‐days feeding period, fecal apparent total N‐nitroso compounds (ATNC) were assayed and colons were scored for MDF. Hot dog diet increased fecal ATNC and the number of MDF per colon compared with the no‐meat control diet (3.0 ± 1.7 vs. 1.2 ± 1.4, p |
| doi_str_mv | 10.1002/ijc.28286 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3788046</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3083526331</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4736-bf44eaa0d4f6f3989a7aff394014722916ea6c982ed67e11df2aa8ebf10cb9bc3</originalsourceid><addsrcrecordid>eNpdks1u1DAUhS0EokNhwQsgS4gFEml9bSd2NpWqEdCikdjA2nIcu_EosQcnKQorHoFn5EnwdIbys_LVOZ_P9c9F6DmQMyCEnvutOaOSyuoBWgGpRUEolA_RKnukEMCqE_RkHLeEAJSEP0YnlAmgpSxXaFjr3vh5wD50vvHTiHcpDnHyMeBmwV2ccBtvcHQY3tCf33-0frBTt_Td0ib9zQebNR_a2dgWD7PxYc_YXW-nLLhofA7GSU_YxD6Gp-iR0_1onx3XU_T53dtP66ti8_H99fpyUxguWFU0jnOrNWm5qxyrZa2FdrngBLigtIbK6srUktq2EhagdVRraRsHxDR1Y9gpujjk7uZmsK2xYUq6V7vkB50WFbVX_zrBd-om3iompCS8ygGvDwHdf9uuLjdqrxGS37sGdguZfXlsluKX2Y6T2sY5hXw_BZwJCjWteaZe_H2k-9DfX5GBV0dAj0b3Lulg_PiHE6IUlMvMnR-4r763y70PRO1nQeVZUHezoK4_rO8K9guThaou</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1437219294</pqid></control><display><type>article</type><title>Calcium inhibits promotion by hot dog of 1,2‐dimethylhydrazine‐induced mucin‐depleted foci in rat colon</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Santarelli, Raphaelle L. ; Naud, Nathalie ; Taché, Sylviane ; Guéraud, Françoise ; Vendeuvre, Jean‐Luc ; Zhou, Lin ; Anwar, Muhammad M. ; Mirvish, Sidney S. ; Corpet, Denis E. ; Pierre, Fabrice H.F.</creator><creatorcontrib>Santarelli, Raphaelle L. ; Naud, Nathalie ; Taché, Sylviane ; Guéraud, Françoise ; Vendeuvre, Jean‐Luc ; Zhou, Lin ; Anwar, Muhammad M. ; Mirvish, Sidney S. ; Corpet, Denis E. ; Pierre, Fabrice H.F.</creatorcontrib><description>Epidemiology suggests that processed meat is associated with colorectal cancer risk, but few experimental studies support this association. We have shown that a model of cured meat made in a pilot workshop promotes preneoplastic lesions, mucin‐depleted foci (MDF) in the colon of rats. This study had two aims: to check if real store‐bought processed meats also promote MDF, and to test if calcium carbonate, which suppresses heme‐induced promotion, can suppress promotion by processed meat. A 14‐day study was done to test the effect of nine purchased cured meats on fecal and urinary biomarkers associated with heme‐induced carcinogenesis promotion. Fecal water from rats given hot dog or fermented raw dry sausage was particularly cytotoxic. These two cured meats were thus given to rats pretreated with 1,2‐dimethylhydrazine, to evaluate their effect on colorectal carcinogenesis. After a 100‐days feeding period, fecal apparent total N‐nitroso compounds (ATNC) were assayed and colons were scored for MDF. Hot dog diet increased fecal ATNC and the number of MDF per colon compared with the no‐meat control diet (3.0 ± 1.7 vs. 1.2 ± 1.4, p < 0.05). In a third study, addition of calcium carbonate (150 µmol/g) to the hot dog diet decreased the number of MDF/colon and fecal ATNC compared with the hot dog diet without calcium carbonate (1.2 ± 1.1 vs. 2.3 ± 1.4, respectively, p < 0.05). This is the first experimental evidence that a widely consumed processed meat promotes colon carcinogenesis in rats. It also shows that dietary prevention of this detrimental effect is possible.
What's new?
The link between dietary intake of processed meats and colorectal cancer risk is intriguing but in need of support from experimental studies, such as the one reported here. Rats pretreated with the cancer‐inducing agent 1,2‐dimethylhydrazine and fed a diet of store‐bought cured meat experienced an increase in the number and size of precancerous lesions (mucin‐depleted foci) in the colon. Hot dog intake was associated with a marked increase in lesions, though the addition of calcium carbonate to the hot dog diet suppressed the promoting effect. Fecal nitroso‐compounds correlated with promotion of carcinogenesis and are potential biomarkers in humans.</description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.28286</identifier><identifier>PMID: 23712585</identifier><identifier>CODEN: IJCNAW</identifier><language>eng</language><publisher>Hoboken, NJ: Wiley-Blackwell</publisher><subject>1,2-Dimethylhydrazine - pharmacology ; Animals ; Biological and medical sciences ; Biomarkers ; Calcium ; Calcium - metabolism ; Cancer ; Carcinogenicity Tests ; Colon - drug effects ; Colon - pathology ; Colonic Neoplasms - chemically induced ; Colonic Neoplasms - metabolism ; Colonic Neoplasms - pathology ; Colorectal cancer ; Diet ; Gastroenterology. Liver. Pancreas. Abdomen ; Heme - metabolism ; Life Sciences ; Meat - toxicity ; Medical research ; Medical sciences ; Mucins - metabolism ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; preneoplastic lesions ; prevention ; processed meat ; Rats ; Risk factors ; Rodents ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>International journal of cancer, 2013-12, Vol.133 (11), p.2533-2541</ispartof><rights>Copyright © 2013 UICC</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013 UICC.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4736-bf44eaa0d4f6f3989a7aff394014722916ea6c982ed67e11df2aa8ebf10cb9bc3</citedby><orcidid>0000-0001-6106-8146 ; 0000-0001-5455-1244</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijc.28286$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijc.28286$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27757248$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23712585$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00828913$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Santarelli, Raphaelle L.</creatorcontrib><creatorcontrib>Naud, Nathalie</creatorcontrib><creatorcontrib>Taché, Sylviane</creatorcontrib><creatorcontrib>Guéraud, Françoise</creatorcontrib><creatorcontrib>Vendeuvre, Jean‐Luc</creatorcontrib><creatorcontrib>Zhou, Lin</creatorcontrib><creatorcontrib>Anwar, Muhammad M.</creatorcontrib><creatorcontrib>Mirvish, Sidney S.</creatorcontrib><creatorcontrib>Corpet, Denis E.</creatorcontrib><creatorcontrib>Pierre, Fabrice H.F.</creatorcontrib><title>Calcium inhibits promotion by hot dog of 1,2‐dimethylhydrazine‐induced mucin‐depleted foci in rat colon</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>Epidemiology suggests that processed meat is associated with colorectal cancer risk, but few experimental studies support this association. We have shown that a model of cured meat made in a pilot workshop promotes preneoplastic lesions, mucin‐depleted foci (MDF) in the colon of rats. This study had two aims: to check if real store‐bought processed meats also promote MDF, and to test if calcium carbonate, which suppresses heme‐induced promotion, can suppress promotion by processed meat. A 14‐day study was done to test the effect of nine purchased cured meats on fecal and urinary biomarkers associated with heme‐induced carcinogenesis promotion. Fecal water from rats given hot dog or fermented raw dry sausage was particularly cytotoxic. These two cured meats were thus given to rats pretreated with 1,2‐dimethylhydrazine, to evaluate their effect on colorectal carcinogenesis. After a 100‐days feeding period, fecal apparent total N‐nitroso compounds (ATNC) were assayed and colons were scored for MDF. Hot dog diet increased fecal ATNC and the number of MDF per colon compared with the no‐meat control diet (3.0 ± 1.7 vs. 1.2 ± 1.4, p < 0.05). In a third study, addition of calcium carbonate (150 µmol/g) to the hot dog diet decreased the number of MDF/colon and fecal ATNC compared with the hot dog diet without calcium carbonate (1.2 ± 1.1 vs. 2.3 ± 1.4, respectively, p < 0.05). This is the first experimental evidence that a widely consumed processed meat promotes colon carcinogenesis in rats. It also shows that dietary prevention of this detrimental effect is possible.
What's new?
The link between dietary intake of processed meats and colorectal cancer risk is intriguing but in need of support from experimental studies, such as the one reported here. Rats pretreated with the cancer‐inducing agent 1,2‐dimethylhydrazine and fed a diet of store‐bought cured meat experienced an increase in the number and size of precancerous lesions (mucin‐depleted foci) in the colon. Hot dog intake was associated with a marked increase in lesions, though the addition of calcium carbonate to the hot dog diet suppressed the promoting effect. Fecal nitroso‐compounds correlated with promotion of carcinogenesis and are potential biomarkers in humans.</description><subject>1,2-Dimethylhydrazine - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Calcium</subject><subject>Calcium - metabolism</subject><subject>Cancer</subject><subject>Carcinogenicity Tests</subject><subject>Colon - drug effects</subject><subject>Colon - pathology</subject><subject>Colonic Neoplasms - chemically induced</subject><subject>Colonic Neoplasms - metabolism</subject><subject>Colonic Neoplasms - pathology</subject><subject>Colorectal cancer</subject><subject>Diet</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Heme - metabolism</subject><subject>Life Sciences</subject><subject>Meat - toxicity</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Mucins - metabolism</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>preneoplastic lesions</subject><subject>prevention</subject><subject>processed meat</subject><subject>Rats</subject><subject>Risk factors</subject><subject>Rodents</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumors</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdks1u1DAUhS0EokNhwQsgS4gFEml9bSd2NpWqEdCikdjA2nIcu_EosQcnKQorHoFn5EnwdIbys_LVOZ_P9c9F6DmQMyCEnvutOaOSyuoBWgGpRUEolA_RKnukEMCqE_RkHLeEAJSEP0YnlAmgpSxXaFjr3vh5wD50vvHTiHcpDnHyMeBmwV2ccBtvcHQY3tCf33-0frBTt_Td0ib9zQebNR_a2dgWD7PxYc_YXW-nLLhofA7GSU_YxD6Gp-iR0_1onx3XU_T53dtP66ti8_H99fpyUxguWFU0jnOrNWm5qxyrZa2FdrngBLigtIbK6srUktq2EhagdVRraRsHxDR1Y9gpujjk7uZmsK2xYUq6V7vkB50WFbVX_zrBd-om3iompCS8ygGvDwHdf9uuLjdqrxGS37sGdguZfXlsluKX2Y6T2sY5hXw_BZwJCjWteaZe_H2k-9DfX5GBV0dAj0b3Lulg_PiHE6IUlMvMnR-4r763y70PRO1nQeVZUHezoK4_rO8K9guThaou</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Santarelli, Raphaelle L.</creator><creator>Naud, Nathalie</creator><creator>Taché, Sylviane</creator><creator>Guéraud, Françoise</creator><creator>Vendeuvre, Jean‐Luc</creator><creator>Zhou, Lin</creator><creator>Anwar, Muhammad M.</creator><creator>Mirvish, Sidney S.</creator><creator>Corpet, Denis E.</creator><creator>Pierre, Fabrice H.F.</creator><general>Wiley-Blackwell</general><general>Wiley Subscription Services, Inc</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6106-8146</orcidid><orcidid>https://orcid.org/0000-0001-5455-1244</orcidid></search><sort><creationdate>20131201</creationdate><title>Calcium inhibits promotion by hot dog of 1,2‐dimethylhydrazine‐induced mucin‐depleted foci in rat colon</title><author>Santarelli, Raphaelle L. ; Naud, Nathalie ; Taché, Sylviane ; Guéraud, Françoise ; Vendeuvre, Jean‐Luc ; Zhou, Lin ; Anwar, Muhammad M. ; Mirvish, Sidney S. ; Corpet, Denis E. ; Pierre, Fabrice H.F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4736-bf44eaa0d4f6f3989a7aff394014722916ea6c982ed67e11df2aa8ebf10cb9bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>1,2-Dimethylhydrazine - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Calcium</topic><topic>Calcium - metabolism</topic><topic>Cancer</topic><topic>Carcinogenicity Tests</topic><topic>Colon - drug effects</topic><topic>Colon - pathology</topic><topic>Colonic Neoplasms - chemically induced</topic><topic>Colonic Neoplasms - metabolism</topic><topic>Colonic Neoplasms - pathology</topic><topic>Colorectal cancer</topic><topic>Diet</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Heme - metabolism</topic><topic>Life Sciences</topic><topic>Meat - toxicity</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Mucins - metabolism</topic><topic>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</topic><topic>preneoplastic lesions</topic><topic>prevention</topic><topic>processed meat</topic><topic>Rats</topic><topic>Risk factors</topic><topic>Rodents</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Santarelli, Raphaelle L.</creatorcontrib><creatorcontrib>Naud, Nathalie</creatorcontrib><creatorcontrib>Taché, Sylviane</creatorcontrib><creatorcontrib>Guéraud, Françoise</creatorcontrib><creatorcontrib>Vendeuvre, Jean‐Luc</creatorcontrib><creatorcontrib>Zhou, Lin</creatorcontrib><creatorcontrib>Anwar, Muhammad M.</creatorcontrib><creatorcontrib>Mirvish, Sidney S.</creatorcontrib><creatorcontrib>Corpet, Denis E.</creatorcontrib><creatorcontrib>Pierre, Fabrice H.F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Santarelli, Raphaelle L.</au><au>Naud, Nathalie</au><au>Taché, Sylviane</au><au>Guéraud, Françoise</au><au>Vendeuvre, Jean‐Luc</au><au>Zhou, Lin</au><au>Anwar, Muhammad M.</au><au>Mirvish, Sidney S.</au><au>Corpet, Denis E.</au><au>Pierre, Fabrice H.F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Calcium inhibits promotion by hot dog of 1,2‐dimethylhydrazine‐induced mucin‐depleted foci in rat colon</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>133</volume><issue>11</issue><spage>2533</spage><epage>2541</epage><pages>2533-2541</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><coden>IJCNAW</coden><abstract>Epidemiology suggests that processed meat is associated with colorectal cancer risk, but few experimental studies support this association. We have shown that a model of cured meat made in a pilot workshop promotes preneoplastic lesions, mucin‐depleted foci (MDF) in the colon of rats. This study had two aims: to check if real store‐bought processed meats also promote MDF, and to test if calcium carbonate, which suppresses heme‐induced promotion, can suppress promotion by processed meat. A 14‐day study was done to test the effect of nine purchased cured meats on fecal and urinary biomarkers associated with heme‐induced carcinogenesis promotion. Fecal water from rats given hot dog or fermented raw dry sausage was particularly cytotoxic. These two cured meats were thus given to rats pretreated with 1,2‐dimethylhydrazine, to evaluate their effect on colorectal carcinogenesis. After a 100‐days feeding period, fecal apparent total N‐nitroso compounds (ATNC) were assayed and colons were scored for MDF. Hot dog diet increased fecal ATNC and the number of MDF per colon compared with the no‐meat control diet (3.0 ± 1.7 vs. 1.2 ± 1.4, p < 0.05). In a third study, addition of calcium carbonate (150 µmol/g) to the hot dog diet decreased the number of MDF/colon and fecal ATNC compared with the hot dog diet without calcium carbonate (1.2 ± 1.1 vs. 2.3 ± 1.4, respectively, p < 0.05). This is the first experimental evidence that a widely consumed processed meat promotes colon carcinogenesis in rats. It also shows that dietary prevention of this detrimental effect is possible.
What's new?
The link between dietary intake of processed meats and colorectal cancer risk is intriguing but in need of support from experimental studies, such as the one reported here. Rats pretreated with the cancer‐inducing agent 1,2‐dimethylhydrazine and fed a diet of store‐bought cured meat experienced an increase in the number and size of precancerous lesions (mucin‐depleted foci) in the colon. Hot dog intake was associated with a marked increase in lesions, though the addition of calcium carbonate to the hot dog diet suppressed the promoting effect. Fecal nitroso‐compounds correlated with promotion of carcinogenesis and are potential biomarkers in humans.</abstract><cop>Hoboken, NJ</cop><pub>Wiley-Blackwell</pub><pmid>23712585</pmid><doi>10.1002/ijc.28286</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-6106-8146</orcidid><orcidid>https://orcid.org/0000-0001-5455-1244</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0020-7136 |
| ispartof | International journal of cancer, 2013-12, Vol.133 (11), p.2533-2541 |
| issn | 0020-7136 1097-0215 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3788046 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 1,2-Dimethylhydrazine - pharmacology Animals Biological and medical sciences Biomarkers Calcium Calcium - metabolism Cancer Carcinogenicity Tests Colon - drug effects Colon - pathology Colonic Neoplasms - chemically induced Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Colorectal cancer Diet Gastroenterology. Liver. Pancreas. Abdomen Heme - metabolism Life Sciences Meat - toxicity Medical research Medical sciences Mucins - metabolism Multiple tumors. Solid tumors. Tumors in childhood (general aspects) preneoplastic lesions prevention processed meat Rats Risk factors Rodents Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | Calcium inhibits promotion by hot dog of 1,2‐dimethylhydrazine‐induced mucin‐depleted foci in rat colon |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T02%3A40%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Calcium%20inhibits%20promotion%20by%20hot%20dog%20of%201,2%E2%80%90dimethylhydrazine%E2%80%90induced%20mucin%E2%80%90depleted%20foci%20in%20rat%20colon&rft.jtitle=International%20journal%20of%20cancer&rft.au=Santarelli,%20Raphaelle%20L.&rft.date=2013-12-01&rft.volume=133&rft.issue=11&rft.spage=2533&rft.epage=2541&rft.pages=2533-2541&rft.issn=0020-7136&rft.eissn=1097-0215&rft.coden=IJCNAW&rft_id=info:doi/10.1002/ijc.28286&rft_dat=%3Cproquest_pubme%3E3083526331%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1437219294&rft_id=info:pmid/23712585&rfr_iscdi=true |