Systematic Review and Meta-analysis of Pharmacological Treatment of the Symptoms of Attention-Deficit/Hyperactivity Disorder in Children with Pervasive Developmental Disorders

Many children with pervasive developmental disorders (PDD) exhibit behaviors and symptoms of attention-deficit/hyperactivity disorder (ADHD). We sought to determine the relative efficacy of medications for treating ADHD symptoms in children with PDD by identifying all double-blind, randomized, place...

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Veröffentlicht in:	Journal of autism and developmental disorders 2013-10, Vol.43 (10), p.2435-2441
Hauptverfasser:	Reichow, Brian, Volkmar, Fred R., Bloch, Michael H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Atomoxetine Hydrochloride Attention Attention Deficit Disorder with Hyperactivity - complications Attention Deficit Disorder with Hyperactivity - drug therapy Attention Deficit Disorders Attention deficit disorders. Hyperactivity Attention Deficit Hyperactivity Disorder Autism Autistic children Behavior Behavior Problems Behavioral Science and Psychology Biological and medical sciences Care and treatment Central Nervous System Stimulants - therapeutic use Child Child and School Psychology Child clinical studies Child Development Child Development Disorders, Pervasive - complications Child, Preschool Children Comorbidity Complications and side effects Developmental disorders Double-Blind Method Drug Therapy Female Humans Hyperactivity Infantile autism Medical sciences Meta Analysis Methylphenidate Methylphenidate - therapeutic use Neuropharmacology Neurosciences Original Paper Outcomes of Treatment Pediatrics Pervasive Developmental Disorders Pharmacology. Drug treatments Propylamines - therapeutic use Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Public Health Randomized Controlled Trials as Topic Risk factors Stimulants Symptoms Symptoms (Individual Disorders) Systematic review
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Beschreibung
Zusammenfassung:	Many children with pervasive developmental disorders (PDD) exhibit behaviors and symptoms of attention-deficit/hyperactivity disorder (ADHD). We sought to determine the relative efficacy of medications for treating ADHD symptoms in children with PDD by identifying all double-blind, randomized, placebo-controlled trials examining the efficacy of medications for treating ADHD symptoms in children with PDD. We located seven trials involving 225 children. A random effects meta-analysis of four methylphenidate trials showed methylphenidate to be effective for treating ADHD symptoms in children with PDD (ES = .67). Several adverse events were greater for children were taking methylphenidate compared to placebo. An individual trial of clonidine and two trials of atomoxetine suggest these agents may also be effective in treating ADHD symptoms in children with PDD.
ISSN:	0162-3257 1573-3432
DOI:	10.1007/s10803-013-1793-z