Capture and Stimulated Release of Circulating Tumor Cells on Polymer-Grafted Silicon Nanostructures

A platform for capture and release of circulating tumor cells is demonstrated by utilizing polymer grafted silicon nanowires. In this platform, integration of ligand‐receptor recognition, nanostructure amplification, and thermal responsive polymers enables a highly efficient and selective capture of...

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Veröffentlicht in:Advanced materials (Weinheim) 2013-03, Vol.25 (11), p.1547-1551
Hauptverfasser: Hou, Shuang, Zhao, Haichao, Zhao, Libo, Shen, Qinglin, Wei, Kevin S., Suh, Daniel Y., Nakao, Aiko, Garcia, Mitch A., Song, Min, Lee, Tom, Xiong, Bin, Luo, Shyh-Chyang, Tseng, Hsian-Rong, Yu, Hsiao-hua
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Sprache:eng
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Zusammenfassung:A platform for capture and release of circulating tumor cells is demonstrated by utilizing polymer grafted silicon nanowires. In this platform, integration of ligand‐receptor recognition, nanostructure amplification, and thermal responsive polymers enables a highly efficient and selective capture of cancer cells. Subsequently, these captured cells are released upon a physical stimulation with outstanding cell viability.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201203185