Development of a DNA vaccine targeting Merkel cell polyomavirus

Highlights ► A preclinical murine MCC tumor model was successfully generated. ► pcDNA3-LT DNA vaccine generated LT-specific CD4+ T cell immune response in vaccinated mice. ► The DNA vaccine demonstrated that the vaccine was capable of generating potent protective and therapeutic antitumor effects. ►...

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Veröffentlicht in:	Vaccine 2012-02, Vol.30 (7), p.1322-1329
Hauptverfasser:	Zeng, Qi, Gomez, Bianca P, Viscidi, Raphael P, Peng, Shiwen, He, Liangmei, Ma, Barbara, Wu, T.-C, Hung, Chien-Fu
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Amino acids Animals Antigen presentation Antigens, Polyomavirus Transforming - genetics Antigens, Polyomavirus Transforming - immunology Antigens, Viral, Tumor - genetics Antigens, Viral, Tumor - immunology Cancer Cancer therapies CD4-Positive T-Lymphocytes - immunology Cellulose acetate Deoxyribonucleic acid DNA DNA vaccine DNA, Viral - genetics DNA, Viral - immunology Female Humans Immune response Immunity, Cellular Injections, Intramuscular Lymphocytes Medical prognosis Melanoma Melanoma, Experimental - genetics Melanoma, Experimental - immunology Melanoma, Experimental - therapy Merkel cell carcinoma Merkel cell polyomavirus Merkel cell polyomavirus - immunology Mice Mice, Inbred C57BL Mortality Mutation Peptides Polyomavirus Polyomavirus Infections - immunology Polyomavirus Infections - prevention & control Polyomavirus Infections - virology Proteins Rodents Tumors Vaccination Vaccines Vaccines, DNA - immunology Vaccines, DNA - therapeutic use Viral Vaccines - immunology Viral Vaccines - therapeutic use
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Beschreibung
Zusammenfassung:	Highlights ► A preclinical murine MCC tumor model was successfully generated. ► pcDNA3-LT DNA vaccine generated LT-specific CD4+ T cell immune response in vaccinated mice. ► The DNA vaccine demonstrated that the vaccine was capable of generating potent protective and therapeutic antitumor effects. ► CD4+ T cell response are the primary mediators for the observed antitumor effects in vaccinated mice.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2011.12.072