Anchors aweigh: protein localization and transport mediated by transmembrane domains

Highlights • TMDs control the intracellular transport of many membrane proteins. • The length and hydrophobicity of TMDs determine their sorting. • Some membrane receptors for sorting TMDs have been identified. • Lipid partitioning may also participate in the sorting of TMDs.

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Veröffentlicht in:	Trends in cell biology 2013-10, Vol.23 (10), p.511-517
Hauptverfasser:	Cosson, Pierre, Perrin, Jackie, Bonifacino, Juan S
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Membrane - chemistry Cell Membrane - metabolism endomembrane system Golgi Apparatus - chemistry Golgi Apparatus - genetics Golgi Apparatus - metabolism Humans Hydrophobic and Hydrophilic Interactions lipid domains Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Pathology protein sorting Protein Structure, Tertiary - genetics protein traffic Protein Transport - genetics Review transmembrane domains transmembrane receptors
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Beschreibung
Zusammenfassung:	Highlights • TMDs control the intracellular transport of many membrane proteins. • The length and hydrophobicity of TMDs determine their sorting. • Some membrane receptors for sorting TMDs have been identified. • Lipid partitioning may also participate in the sorting of TMDs.
ISSN:	0962-8924 1879-3088
DOI:	10.1016/j.tcb.2013.05.005