Amyloidogenic peptide homologous to fragment 129-148 of human myocilin

Amyloidogenic peptide homologous to fragment 129-148 of human myocilin

Myocilin is a protein with a molecular weight near 50 kDa. It is expressed in almost all organs and tissues. We showed that the peptide DQLETQTRELETAYSNLLRD corresponding to N-terminal Leucine zipper motif (LZM) of the protein is able to form amyloid-like fibrils. The possible role of this motif in...

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Veröffentlicht in:Prion 2013-05, Vol.7 (3), p.248-253
Hauptverfasser: Egorov, Vladimir V, Grudinina, Natalia A, Lebedev, Dmitry V, Shaldzhyan, Aram A, Slita, Alexander V, Sirotkin, Alexey K, Vasin, Andrey V, Shavlovsky, Michael M
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Amyloid - chemistry
Amyloid - metabolism
Amyloid - ultrastructure
Cytoskeletal Proteins - chemistry
Cytoskeletal Proteins - metabolism
Cytoskeletal Proteins - ultrastructure
Eye Proteins - chemistry
Eye Proteins - metabolism
Eye Proteins - ultrastructure
Glycoproteins - chemistry
Glycoproteins - metabolism
Glycoproteins - ultrastructure
Humans
Leucine Zippers
Molecular Sequence Data
Short Communication
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Zusammenfassung:Myocilin is a protein with a molecular weight near 50 kDa. It is expressed in almost all organs and tissues. We showed that the peptide DQLETQTRELETAYSNLLRD corresponding to N-terminal Leucine zipper motif (LZM) of the protein is able to form amyloid-like fibrils. The possible role of this motif in myocilin aggregation is discussed.
ISSN:1933-6896
1933-690X
DOI:10.4161/pri.24239