Cracking the O -GlcNAc code in metabolism

Cracking the O -GlcNAc code in metabolism

Highlights • O-GlcNAc is a nutrient sensor and regulatory molecular switch. • O-GlcNAc is a negative regulator of insulin signaling. • O-GlcNAc is crucially involved in transcriptional regulation of metabolism and the circadian clock. • Aberrant O-GlcNAcylation has implications in a wide range of me...

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Veröffentlicht in:Trends in endocrinology and metabolism 2013-06, Vol.24 (6), p.301-309
Hauptverfasser: Ruan, Hai-Bin, Singh, Jay Prakash, Li, Min-Dian, Wu, Jing, Yang, Xiaoyong
Format: Artikel
Sprache:eng
Schlagworte:
Acetylglucosamine - metabolism
Animals
cancer metabolism
circadian rhythm
Circadian Rhythm - physiology
Endocrinology & Metabolism
hexosamine biosynthesis
Hexosamines - biosynthesis
Humans
insulin resistance
mitochondria
Mitochondria - metabolism
O-GlcNAc
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Beschreibung
Zusammenfassung:Highlights • O-GlcNAc is a nutrient sensor and regulatory molecular switch. • O-GlcNAc is a negative regulator of insulin signaling. • O-GlcNAc is crucially involved in transcriptional regulation of metabolism and the circadian clock. • Aberrant O-GlcNAcylation has implications in a wide range of metabolic diseases.
ISSN:1043-2760
1879-3061
DOI:10.1016/j.tem.2013.02.002