Voxel-based morphometric gray matter correlates of posttraumatic stress disorder

Highlights • Voxel-morphometric correlates of PTSD varied with severity and symptom clusters. • Greater severity predicted greater amygdala/hippocampus gray matter. • Greater avoidance/numbing predicted greater amygdala/hippocampus gray matter. • Greater hyper-arousal was associated with less medial...

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Veröffentlicht in:	Journal of anxiety disorders 2013-05, Vol.27 (4), p.413-419
Hauptverfasser:	Weber, Mareen, Killgore, William D.S, Rosso, Isabelle M, Britton, Jennifer C, Schwab, Zachary J, Weiner, Melissa R, Simon, Naomi M, Pollack, Mark H, Rauch, Scott L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Amygdala Amygdala - pathology Anxiety disorders. Neuroses Avoidance Biological and medical sciences Brain - pathology Burden Chronic post-traumatic stress disorder Cortex Female Frontal Lobe - pathology Hippocampus Hippocampus - pathology Humans Magnetic Resonance Imaging Male Medical sciences Middle Aged Neuroimaging Post-traumatic stress disorder Posttraumatic stress disorder Prefrontal cortex Psychiatric Status Rating Scales Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Severity Severity of Illness Index Stress Disorders, Post-Traumatic - pathology Symptoms Young Adult
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Zusammenfassung:	Highlights • Voxel-morphometric correlates of PTSD varied with severity and symptom clusters. • Greater severity predicted greater amygdala/hippocampus gray matter. • Greater avoidance/numbing predicted greater amygdala/hippocampus gray matter. • Greater hyper-arousal was associated with less medial PFC gray matter. • This suggests differential structural remodeling in associated brain regions.
ISSN:	0887-6185 1873-7897
DOI:	10.1016/j.janxdis.2013.04.004