Localization of a major susceptibility locus influencing preterm birth

Preterm birth (PTB) is a complex trait, but little is known regarding its major genetic determinants. The objective of this study is to localize genes that influence susceptibility to PTB in Mexican Americans (MAs), a minority population in the USA, using predominantly microfilmed birth certificate-...

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Veröffentlicht in:	Molecular human reproduction 2013-10, Vol.19 (10), p.687-696
Hauptverfasser:	Chittoor, G, Farook, V S, Puppala, S, Fowler, S P, Schneider, J, Dyer, T D, Cole, S A, Lynch, J L, Curran, J E, Almasy, L, Maccluer, J W, Comuzzie, A G, Hale, D E, Ramamurthy, R S, Dudley, D J, Moses, E K, Arya, R, Lehman, D M, Jenkinson, C P, Bradshaw, B S, Defronzo, R A, Blangero, J, Duggirala, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromosomes, Human, Pair 18 - genetics Female Genetic Linkage - genetics Genetic Predisposition to Disease - genetics Humans Mexican Americans - genetics Pregnancy Premature Birth - genetics
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Beschreibung
Zusammenfassung:	Preterm birth (PTB) is a complex trait, but little is known regarding its major genetic determinants. The objective of this study is to localize genes that influence susceptibility to PTB in Mexican Americans (MAs), a minority population in the USA, using predominantly microfilmed birth certificate-based data obtained from the San Antonio Family Birth Weight Study. Only 1302 singleton births from 288 families with information on PTB and significant covariates were considered for genetic analysis. PTB is defined as a childbirth that occurs at
ISSN:	1360-9947 1460-2407
DOI:	10.1093/molehr/gat036