Differential striatal spine pathology in Parkinson’s disease and cocaine addiction: A key role of dopamine?
Graphical abstract Striatal projection neurons undergo a massive loss of dendritic spines in Parkinson’s disease, while they display an abnormal overgrowth of “thin and immature” spines after chronic cocaine exposure. Accumbens D1 dopamine receptor-containing neurons are preferentially affected in r...
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| Veröffentlicht in: | Neuroscience 2013-10, Vol.251, p.2-20 |
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| creator | Villalba, R.M Smith, Y |
| description | Graphical abstract Striatal projection neurons undergo a massive loss of dendritic spines in Parkinson’s disease, while they display an abnormal overgrowth of “thin and immature” spines after chronic cocaine exposure. Accumbens D1 dopamine receptor-containing neurons are preferentially affected in response to chronic cocaine exposure. Dopamine and glutamate are key regulators of this spine plasticity. Opposite calcium-mediated regulation of the myocyte enhancer factor 2 (MEF2) induces these structural changes. |
| doi_str_mv | 10.1016/j.neuroscience.2013.07.011 |
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Accumbens D1 dopamine receptor-containing neurons are preferentially affected in response to chronic cocaine exposure. Dopamine and glutamate are key regulators of this spine plasticity. Opposite calcium-mediated regulation of the myocyte enhancer factor 2 (MEF2) induces these structural changes.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/j.neuroscience.2013.07.011</identifier><identifier>PMID: 23867772</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>accumbens ; Animals ; Basal Ganglia - pathology ; cocaine ; Cocaine-Related Disorders - pathology ; Corpus Striatum - pathology ; corticostriatal ; Dendritic Spines - pathology ; Dopamine - metabolism ; Dopaminergic Neurons - pathology ; GABAergic Neurons ; glutamate ; Humans ; MEF2 Transcription Factors - metabolism ; Neurology ; Nucleus Accumbens - pathology ; Parkinson Disease - pathology ; striatum ; thalamostriatal</subject><ispartof>Neuroscience, 2013-10, Vol.251, p.2-20</ispartof><rights>IBRO</rights><rights>2013 IBRO</rights><rights>Copyright © 2013 IBRO. Published by Elsevier Ltd. 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Opposite calcium-mediated regulation of the myocyte enhancer factor 2 (MEF2) induces these structural changes.</description><subject>accumbens</subject><subject>Animals</subject><subject>Basal Ganglia - pathology</subject><subject>cocaine</subject><subject>Cocaine-Related Disorders - pathology</subject><subject>Corpus Striatum - pathology</subject><subject>corticostriatal</subject><subject>Dendritic Spines - pathology</subject><subject>Dopamine - metabolism</subject><subject>Dopaminergic Neurons - pathology</subject><subject>GABAergic Neurons</subject><subject>glutamate</subject><subject>Humans</subject><subject>MEF2 Transcription Factors - metabolism</subject><subject>Neurology</subject><subject>Nucleus Accumbens - pathology</subject><subject>Parkinson Disease - pathology</subject><subject>striatum</subject><subject>thalamostriatal</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUt1qFDEYDWKx29VXkOD9TPMzScZeVEprVSgoqNchm3xps51NhmS2sHe-hq_nkzTD1tJ6ZW4SyDnn4zvnIPSOkpYSKo_XbYRtTsUGiBZaRihviWoJpS_QgvaKN0p03Uu0IJzIphOMHaKjUtakHtHxV-iQ8V4qpdgCbS6C95AhTsEMuEw5mGl-jCECHs10k4Z0vcMh4m8m34ZYUvzz63fBLhQwBbCJDttkzQw3zgU7hRRP8Bm-hR3OaQCcPHZpNJuK-PAaHXgzFHjzcC_Rz8uPP84_N1dfP305P7tqrCT91EjWdcJTZTlRnZKq895J4zkoY937lQQQ0nsmqCdWCM-FXyllpSdmZWjvGV-i073uuF1twNm6XjaDHnPYmLzTyQT9_CeGG32d7jRXqifVwSU62QvY6nPJ4B-5lOg5BL3WT0PQcwiaKF1DqOS3T6c_Uv-6XgEXewBUD-4CZP0g40IGO2mXwv_NOf1Hxg4hBmuGaj6UddrmWF3WVBemif4-12FuA-W1B72k_B6yarkY</recordid><startdate>20131022</startdate><enddate>20131022</enddate><creator>Villalba, R.M</creator><creator>Smith, Y</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20131022</creationdate><title>Differential striatal spine pathology in Parkinson’s disease and cocaine addiction: A key role of dopamine?</title><author>Villalba, R.M ; Smith, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c608t-62445f17c30747674ffd6af3e7acd9b6ee56ff251f0c55f35fb77c6f0aba18f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>accumbens</topic><topic>Animals</topic><topic>Basal Ganglia - pathology</topic><topic>cocaine</topic><topic>Cocaine-Related Disorders - pathology</topic><topic>Corpus Striatum - pathology</topic><topic>corticostriatal</topic><topic>Dendritic Spines - pathology</topic><topic>Dopamine - metabolism</topic><topic>Dopaminergic Neurons - pathology</topic><topic>GABAergic Neurons</topic><topic>glutamate</topic><topic>Humans</topic><topic>MEF2 Transcription Factors - metabolism</topic><topic>Neurology</topic><topic>Nucleus Accumbens - pathology</topic><topic>Parkinson Disease - pathology</topic><topic>striatum</topic><topic>thalamostriatal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Villalba, R.M</creatorcontrib><creatorcontrib>Smith, Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Villalba, R.M</au><au>Smith, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential striatal spine pathology in Parkinson’s disease and cocaine addiction: A key role of dopamine?</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2013-10-22</date><risdate>2013</risdate><volume>251</volume><spage>2</spage><epage>20</epage><pages>2-20</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><abstract>Graphical abstract Striatal projection neurons undergo a massive loss of dendritic spines in Parkinson’s disease, while they display an abnormal overgrowth of “thin and immature” spines after chronic cocaine exposure. Accumbens D1 dopamine receptor-containing neurons are preferentially affected in response to chronic cocaine exposure. Dopamine and glutamate are key regulators of this spine plasticity. Opposite calcium-mediated regulation of the myocyte enhancer factor 2 (MEF2) induces these structural changes.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>23867772</pmid><doi>10.1016/j.neuroscience.2013.07.011</doi><tpages>19</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0306-4522 |
| ispartof | Neuroscience, 2013-10, Vol.251, p.2-20 |
| issn | 0306-4522 1873-7544 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | accumbens Animals Basal Ganglia - pathology cocaine Cocaine-Related Disorders - pathology Corpus Striatum - pathology corticostriatal Dendritic Spines - pathology Dopamine - metabolism Dopaminergic Neurons - pathology GABAergic Neurons glutamate Humans MEF2 Transcription Factors - metabolism Neurology Nucleus Accumbens - pathology Parkinson Disease - pathology striatum thalamostriatal |
| title | Differential striatal spine pathology in Parkinson’s disease and cocaine addiction: A key role of dopamine? |
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