Differential striatal spine pathology in Parkinson’s disease and cocaine addiction: A key role of dopamine?

Graphical abstract Striatal projection neurons undergo a massive loss of dendritic spines in Parkinson’s disease, while they display an abnormal overgrowth of “thin and immature” spines after chronic cocaine exposure. Accumbens D1 dopamine receptor-containing neurons are preferentially affected in r...

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Veröffentlicht in:	Neuroscience 2013-10, Vol.251, p.2-20
Hauptverfasser:	Villalba, R.M, Smith, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	accumbens Animals Basal Ganglia - pathology cocaine Cocaine-Related Disorders - pathology Corpus Striatum - pathology corticostriatal Dendritic Spines - pathology Dopamine - metabolism Dopaminergic Neurons - pathology GABAergic Neurons glutamate Humans MEF2 Transcription Factors - metabolism Neurology Nucleus Accumbens - pathology Parkinson Disease - pathology striatum thalamostriatal
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Zusammenfassung:	Graphical abstract Striatal projection neurons undergo a massive loss of dendritic spines in Parkinson’s disease, while they display an abnormal overgrowth of “thin and immature” spines after chronic cocaine exposure. Accumbens D1 dopamine receptor-containing neurons are preferentially affected in response to chronic cocaine exposure. Dopamine and glutamate are key regulators of this spine plasticity. Opposite calcium-mediated regulation of the myocyte enhancer factor 2 (MEF2) induces these structural changes.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.07.011