High Expression of H3K27me3 Is an Independent Predictor of Worse Outcome in Patients with Urothelial Carcinoma of Bladder Treated with Radical Cystectomy

High Expression of H3K27me3 Is an Independent Predictor of Worse Outcome in Patients with Urothelial Carcinoma of Bladder Treated with Radical Cystectomy

It has been suggested that trimethylation of lysine 27 on histone H3 (H3K27me3) is a crucial epigenetic process in tumorigenesis. However, the expression pattern of H3K27me3 and its clinicopathological/prognostic significance in urothelial carcinoma of bladder (UCB) are unclear. In this study, upreg...

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Veröffentlicht in:BioMed research international 2013-01, Vol.2013 (2013), p.1-8
Hauptverfasser: Xie, Dan, Zhou, Fangjian, Jiang, Lijuan, Liu, Zhouwei, Zhang, Zhiling, Mai, Shijuan, Liao, Yiji, Li, Yonghong, Liu, Jianye, Zeng, Yixin
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Biomarkers, Tumor - biosynthesis
Biomedical research
Bladder
Cancer
Cancer therapies
Carcinoma - genetics
Carcinoma - mortality
Carcinoma - pathology
Carcinoma - surgery
Cystectomy
Cystectomy - adverse effects
Data processing
Evaluation
Female
Gene expression
Gene Expression Regulation, Neoplastic
Histone Demethylases - biosynthesis
Histone Demethylases - genetics
Humans
Lymphatic Metastasis - genetics
Lymphatic Metastasis - pathology
Male
Methylation
Middle Aged
Mortality
Pathology
Prognosis
Proteins
Studies
Treatment Outcome
Urinary Bladder Neoplasms - genetics
Urinary Bladder Neoplasms - mortality
Urinary Bladder Neoplasms - pathology
Urinary Bladder Neoplasms - surgery
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Zusammenfassung:It has been suggested that trimethylation of lysine 27 on histone H3 (H3K27me3) is a crucial epigenetic process in tumorigenesis. However, the expression pattern of H3K27me3 and its clinicopathological/prognostic significance in urothelial carcinoma of bladder (UCB) are unclear. In this study, upregulated expression of H3K27me3 protein was observed in the majority of UCBs by Western blotting. High expression of H3K27me3 was examined by IHC in 59/126 (46.8%) of UCB tissues and in 18/72 (25.0%) of normal urothelial bladder epithelial tissues (P=0.002). High expression of H3K27me3 was associated with multifocal tumors and lymph node metastases (P
ISSN:2314-6133
2314-6141
DOI:10.1155/2013/390482