Acute Infection Induces a Metastatic Niche: A Double Menace for Cancer Patients

Tumor-derived factors can induce a premetastatic niche, yet little is known about how metastatic microenvironments are influenced by external insults, such as acute infections commonly seen in patients with cancer. New findings reveal increased metastasis to the lung after acute bacterial infection...

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Veröffentlicht in:	Clinical cancer research 2013-09, Vol.19 (17), p.4547-4549
Hauptverfasser:	SMITH, Heath A, YIBIN KANG
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - genetics Animals Antineoplastic agents Biological and medical sciences Humans Lung Neoplasms - genetics Medical sciences Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Pharmacology. Drug treatments Receptors, CXCR4 - genetics Tumors Ubiquitin - genetics
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Zusammenfassung:	Tumor-derived factors can induce a premetastatic niche, yet little is known about how metastatic microenvironments are influenced by external insults, such as acute infections commonly seen in patients with cancer. New findings reveal increased metastasis to the lung after acute bacterial infection via the CXCR4/ubiquitin axis, suggesting new targets for antimetastasis therapeutics.
ISSN:	1078-0432 1557-3265
DOI:	10.1158/1078-0432.CCR-13-1524