The metabolic roles of the endosymbiotic organelles of Toxoplasma and Plasmodium spp

Highlights • Toxoplasma and Plasmodium possess two organelles of endosymbiotic origin: the apicoplast, and the mitochondrion. • The mitochondrion hosts a complete TCA cycle and an electron transport chain lacking complex I. Glutamine catabolism contributes to the TCA cycle. • Haem biosynthesis is an...

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Veröffentlicht in:	Current opinion in microbiology 2013-08, Vol.16 (4), p.452-458
Hauptverfasser:	Sheiner, Lilach, Vaidya, Akhil B, McFadden, Geoffrey I
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apicomplexa Apicoplasts - metabolism Citric Acid Cycle coevolution electron transfer Electron Transport fatty acids glutamine Humans isoprenoids Lipid Metabolism liver Mammals metabolites mitochondria Mitochondria - metabolism Models, Biological parasites Pathology photosynthesis Plasmodium Plasmodium - metabolism tachyzoites Toxoplasma Toxoplasma - metabolism tricarboxylic acid cycle
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Beschreibung
Zusammenfassung:	Highlights • Toxoplasma and Plasmodium possess two organelles of endosymbiotic origin: the apicoplast, and the mitochondrion. • The mitochondrion hosts a complete TCA cycle and an electron transport chain lacking complex I. Glutamine catabolism contributes to the TCA cycle. • Haem biosynthesis is an extremely unusual chimerical pathway shared between the two organelles and the cytoplasm. • Isoprenoid precursor synthesis and fatty acid synthesis are essential roles of the apicoplast. Different life stages show differential dependencies on these pathways.
ISSN:	1369-5274 1879-0364
DOI:	10.1016/j.mib.2013.07.003