A Simple, Efficient Synthesis of 2-Aryl Benzimidazoles Using Silica Supported Periodic Acid Catalyst and Evaluation of Anticancer Activity

A Simple, Efficient Synthesis of 2-Aryl Benzimidazoles Using Silica Supported Periodic Acid Catalyst and Evaluation of Anticancer Activity

A new, efficient method for the synthesis of 2-aryl substituted benzimidazole by using silica supported periodic acid (H5IO6-SiO2) as a catalyst has been developed. The salient feature of the present method includes mild reaction condition, short reaction time, high yield and easy workup procedure....

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Veröffentlicht in:ISRN Organic Chemistry 2013, Vol.2013, p.453682-7
Hauptverfasser: Sontakke, Vyankat A., Ghosh, Sougata, Lawande, Pravin P., Chopade, Balu A., Shinde, Vaishali S.
Format: Artikel
Sprache:eng
Schlagworte:
Acids
Aldehydes
Antitumor activity
Cancer
Colleges & universities
Scholarships & fellowships
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Zusammenfassung:A new, efficient method for the synthesis of 2-aryl substituted benzimidazole by using silica supported periodic acid (H5IO6-SiO2) as a catalyst has been developed. The salient feature of the present method includes mild reaction condition, short reaction time, high yield and easy workup procedure. The synthesized benzimidazoles exhibited potent anticancer activity against MCF7 and HL60 cell lines.
ISSN:2090-5149
2090-5157
2090-5157
DOI:10.1155/2013/453682