Characterization of a novel polyclonal anti-hypusine antibody

The translation factor eIF5A is the only protein known to contain the amino acid hypusine, which is formed posttranslationally. Hypusinated eIF5A is necessary for cellular proliferation and responses to extracellular stressors, and has been proposed as a target for pharmacologic therapy. Here, we pr...

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Veröffentlicht in:	SpringerPlus 2013-08, Vol.2 (1), p.421-421, Article 421
Hauptverfasser:	Nishiki, Yurika, Farb, Thomas B, Friedrich, Jessica, Bokvist, Krister, Mirmira, Raghavendra G, Maier, Bernhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Humanities and Social Sciences multidisciplinary Science Science (multidisciplinary) Technical Note
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The translation factor eIF5A is the only protein known to contain the amino acid hypusine, which is formed posttranslationally. Hypusinated eIF5A is necessary for cellular proliferation and responses to extracellular stressors, and has been proposed as a target for pharmacologic therapy. Here, we provide the first comprehensive characterization of a novel polyclonal antibody (IU-88) that specifically recognizes the hypusinated eIF5A. IU-88 will be useful for the investigation of eIF5A biology and for the development of assays recognizing hypusinated eIF5A.
ISSN:	2193-1801 2193-1801
DOI:	10.1186/2193-1801-2-421