Molecular subsets of mantle cell lymphoma defined by the IGHV mutational status and SOX11 expression have distinct biological and clinical features

Mantle cell lymphoma (MCL) is a heterogeneous disease with most patients following an aggressive clinical course while others have an indolent behavior. We performed an integrative and multidisciplinary analysis of 177 MCL to determine whether the immunogenetic features of the clonotypic B cell rece...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2012-08, Vol.72 (20), p.5307-5316
Hauptverfasser:	Navarro, Alba, Clot, Guillem, Royo, Cristina, Jares, Pedro, Hadzidimitriou, Anastasia, Agathangelidis, Andreas, Bikos, Vasilis, Darzentas, Nikos, Papadaki, Theodora, Salaverria, Itziar, Pinyol, Magda, Puig, Xavier, Palomero, Jara, Vegliante, Maria Carmela, Amador, Virgina, Martinez-Trillos, Alejandra, Stefancikova, Lenka, Wiestner, Adrian, Wilson, Wyndham, Pott, Christiane, Calasanz, Maria Jose, Trim, Nicola, Erber, Wendy, Sander, Birgitta, Ott, German, Rosenwald, Andreas, Colomer, Dolors, Giné, Eva, Siebert, Reiner, Lopez-Guillermo, Armando, Stamatopoulos, Kostas, Beà, Sílvia, Campo, Elías
Format:	Artikel
Sprache:	eng
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Zusammenfassung:	Mantle cell lymphoma (MCL) is a heterogeneous disease with most patients following an aggressive clinical course while others have an indolent behavior. We performed an integrative and multidisciplinary analysis of 177 MCL to determine whether the immunogenetic features of the clonotypic B cell receptors may identify different subsets of tumors. ‘Truly unmutated’ (100% identity) IGHV genes were found in 24% cases, 40% were ‘minimally/borderline mutated’ (99.9-97%), 19% ‘significantly mutated’ (96.9-95%) and 17% ‘hypermutated’ (
ISSN:	0008-5472 1538-7445
DOI:	10.1158/0008-5472.CAN-12-1615