Sarcoplasmic Reticulum K+ (TRIC) Channel Does Not Carry Essential Countercurrent during Ca2+ Release

Sarcoplasmic Reticulum K+ (TRIC) Channel Does Not Carry Essential Countercurrent during Ca2+ Release

The charge translocation associated with sarcoplasmic reticulum (SR) Ca2+ efflux is compensated for by a simultaneous SR K+ influx. This influx is essential because, with no countercurrent, the SR membrane potential (Vm) would quickly (

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Bibliographische Detailangaben
Veröffentlicht in:Biophysical journal 2013-09, Vol.105 (5), p.1151-1160
Hauptverfasser: Guo, Tao, Nani, Alma, Shonts, Stephen, Perryman, Matthew, Chen, Haiyan, Shannon, Thomas, Gillespie, Dirk, Fill, Michael
Format: Artikel
Sprache:eng
Schlagworte:
calcium
cardiomyocytes
cesium
Channels and Transporters
membrane potential
potassium
potassium channels
sarcoplasmic reticulum
sodium
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Zusammenfassung:The charge translocation associated with sarcoplasmic reticulum (SR) Ca2+ efflux is compensated for by a simultaneous SR K+ influx. This influx is essential because, with no countercurrent, the SR membrane potential (Vm) would quickly (
ISSN:0006-3495
1542-0086
DOI:10.1016/j.bpj.2013.07.042