Young and elderly patients with type 2 diabetes have optimal B cell responses to the seasonal influenza vaccine

Highlights • Age decreases serum influenza vaccine response in healthy but not in T2D individuals. • Age decreases B cell biomarkers of optimal responses in healthy but not in T2D individuals. • We report high levels of B cell-derived TNF-α in elderly individuals and T2D patients. • We also report h...

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Veröffentlicht in:	Vaccine 2013-08, Vol.31 (35), p.3603-3610
Hauptverfasser:	Frasca, Daniela, Diaz, Alain, Romero, Maria, Mendez, Nicholas V, Landin, Ana Marie, Ryan, John G, Blomberg, Bonnie B
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation-induced cytidine deaminase Adult Aged Aged, 80 and over Allergy and Immunology Antibodies, Viral - blood Antibodies, Viral - immunology Antibody responses Applied microbiology B-lymphocytes B-Lymphocytes - immunology Biological and medical sciences biomarkers Biomarkers - blood blood serum cytidine deaminase Cytidine Deaminase - genetics Cytidine Deaminase - metabolism Diabetes Mellitus, Type 2 - immunology elderly enzyme-linked immunosorbent assay Female Fundamental and applied biological sciences. Psychology hemagglutination Hemagglutination Inhibition Tests Humans Immune response Immune system Immunologic Memory - immunology Inflammation Inflammation - immunology Influenza Influenza vaccine Influenza Vaccines - administration & dosage Influenza Vaccines - immunology Influenza, Human - immunology Influenza, Human - prevention & control Male Medical research Microbiology Middle Aged Mortality noninsulin-dependent diabetes mellitus patients RNA, Messenger - biosynthesis tumor necrosis factor-alpha Tumor Necrosis Factor-alpha - blood Type 2 diabetes Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Young Adult
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Zusammenfassung:	Highlights • Age decreases serum influenza vaccine response in healthy but not in T2D individuals. • Age decreases B cell biomarkers of optimal responses in healthy but not in T2D individuals. • We report high levels of B cell-derived TNF-α in elderly individuals and T2D patients. • We also report hyperactivation of the innate immune system in T2D which would stimulate B cells.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.05.003