Combination of Local Transcatheter Arterial Chemoembolization and Systemic Anti-Angiogenic Therapy for Unresectable Hepatocellular Carcinoma

The pathophysiologic complexity of hepatocellular carcinoma (HCC) and underlying hepatic cirrhosis, make optimal treatment choice a clinical challenge. The radical change in the treatment algorithm of patients with advanced unresectable HCC over the past 7 years, with the introduction of anti-angiog...

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Veröffentlicht in:Liver cancer (Basel ) 2012-11, Vol.1 (3-4), p.201-215
Hauptverfasser: Liapi, Eleni, Geschwind, Jean-Francois H.
Format: Artikel
Sprache:eng
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Zusammenfassung:The pathophysiologic complexity of hepatocellular carcinoma (HCC) and underlying hepatic cirrhosis, make optimal treatment choice a clinical challenge. The radical change in the treatment algorithm of patients with advanced unresectable HCC over the past 7 years, with the introduction of anti-angiogenic agents in patients with only preserved liver function reflect this challenge.Even though data from studies on the combination of transcatheter arterial chemoembolization and anti-angiogenic agents demonstrate a survival advantage in selected patients, this combination is not straightforward. In this review, we’ll examine current data of administering anti-angiogenic therapy in combination with transcatheter arterial chemoembolization and critically evaluate the progress and gaps in current knowledge.
ISSN:2235-1795
1664-5553
DOI:10.1159/000343835