Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta‐analysis
See also Machin SJ, Briggs C. Mean platelet volume: a quick, easy determinant of thrombotic risk? This issue, pp 146–7. Summary. Aim: To determine whether an association exists between mean platelet volume (MPV) and acute myocardial infarction (AMI) and other cardiovascular events. Platelet activi...
Gespeichert in:
| Veröffentlicht in: | Journal of thrombosis and haemostasis 2010-01, Vol.8 (1), p.148-156 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 156 |
|---|---|
| container_issue | 1 |
| container_start_page | 148 |
| container_title | Journal of thrombosis and haemostasis |
| container_volume | 8 |
| creator | CHU, S. G. BECKER, R. C. BERGER, P. B. BHATT, D. L. EIKELBOOM, J. W. KONKLE, B. MOHLER, E. R. REILLY, M. P. BERGER, J. S. |
| description | See also Machin SJ, Briggs C. Mean platelet volume: a quick, easy determinant of thrombotic risk? This issue, pp 146–7.
Summary. Aim:
To determine whether an association exists between mean platelet volume (MPV) and acute myocardial infarction (AMI) and other cardiovascular events. Platelet activity is a major culprit in atherothrombotic events. MPV, which is widely available in clinical practice, is a potentially useful biomarker of platelet activity in the setting of cardiovascular disease. Methods and Results: We performed a systematic review and meta‐analysis investigating the association between MPV and AMI, all‐cause mortality following myocardial infarction, and restenosis following coronary angioplasty. Results were pooled using random‐effects modeling. Pooled results from 16 cross‐sectional studies involving 2809 patients investigating the association of MPV and AMI indicated that MPV was significantly higher in those with AMI than those without AMI [mean difference 0.92 fL, 95% confidence interval (CI) 0.67–1.16, P |
| doi_str_mv | 10.1111/j.1538-7836.2009.03584.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3755496</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>21342170</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6254-e045ad07c3d9a4d515bda2e220a746a15f7f0f70f2360c45f97330af7d041df33</originalsourceid><addsrcrecordid>eNqNkc9u1DAQhyMEoqXwCsgnOG3w3zhBAglVQEFFXMrZmtpj8OLEi51suzcegWfkSUjYpcAF4YtHmm9-Y-urKsJozebzZF0zJdqVbkVTc0q7mgrVyvr6VnV807j9q-6EOKrulbKmlHWK07vVEeuajslWHVf2HcJANhFGjDiSbYpTjwQKAbLJ6IIdUybJEwvZhbSFYqcImeRQPj-dmbIrI_YwBksybgNeERgc6XGE71-_wQBxV0K5X93xEAs-ONwn1YdXLy9Oz1bn71-_OX1xvrINV3KFVCpwVFvhOpBOMXXpgCPnFLRsgCmvPfWaei4aaqXynRaCgteOSua8ECfV833uZrrs0VkcxgzRbHLoIe9MgmD-7gzhk_mYtkZopWTXzAGPDwE5fZmwjKYPxWKMMGCaipn3KSkavqx69E-SMyE503QG2z1ocyolo795DqNmcWnWZtFkFmVmcWl-ujTX8-jDP7_ze_Agbwae7YGrEHH338Hm7cXZUokfFlSwdg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>21342170</pqid></control><display><type>article</type><title>Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta‐analysis</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>CHU, S. G. ; BECKER, R. C. ; BERGER, P. B. ; BHATT, D. L. ; EIKELBOOM, J. W. ; KONKLE, B. ; MOHLER, E. R. ; REILLY, M. P. ; BERGER, J. S.</creator><creatorcontrib>CHU, S. G. ; BECKER, R. C. ; BERGER, P. B. ; BHATT, D. L. ; EIKELBOOM, J. W. ; KONKLE, B. ; MOHLER, E. R. ; REILLY, M. P. ; BERGER, J. S.</creatorcontrib><description>See also Machin SJ, Briggs C. Mean platelet volume: a quick, easy determinant of thrombotic risk? This issue, pp 146–7.
Summary. Aim:
To determine whether an association exists between mean platelet volume (MPV) and acute myocardial infarction (AMI) and other cardiovascular events. Platelet activity is a major culprit in atherothrombotic events. MPV, which is widely available in clinical practice, is a potentially useful biomarker of platelet activity in the setting of cardiovascular disease. Methods and Results: We performed a systematic review and meta‐analysis investigating the association between MPV and AMI, all‐cause mortality following myocardial infarction, and restenosis following coronary angioplasty. Results were pooled using random‐effects modeling. Pooled results from 16 cross‐sectional studies involving 2809 patients investigating the association of MPV and AMI indicated that MPV was significantly higher in those with AMI than those without AMI [mean difference 0.92 fL, 95% confidence interval (CI) 0.67–1.16, P < 0.001). In subgroup analyses, significant differences in MPV existed between subjects with AMI, subjects with stable coronary disease (P < 0.001), and stable controls (P < 0.001), but not vs. those with unstable angina (P = 0.24). Pooled results from three cohort studies involving 3184 patients evaluating the risk of death following AMI demonstrated that an elevated MPV increased the odds of death as compared with a normal MPV (11.5% vs. 7.1%, odds ratio 1.65, 95% CI 1.12–2.52, P = 0.012). Pooled results from five cohort studies involving 430 patients who underwent coronary angioplasty revealed that MPV was significantly higher in patients who developed restenosis than in those who did not develop restenosis (mean difference 0.98 fL, 95% CI 0.74–1.21, P < 0.001). Conclusions: Elevated MPV is associated with AMI, mortality following myocardial infarction, and restenosis following coronary angioplasty. These data suggest that MPV is a potentially useful prognostic biomarker in patients with cardiovascular disease. Whether the relationship is causal, and whether MPV should influence practice or guide therapy, remains unknown.</description><identifier>ISSN: 1538-7933</identifier><identifier>ISSN: 1538-7836</identifier><identifier>EISSN: 1538-7836</identifier><identifier>DOI: 10.1111/j.1538-7836.2009.03584.x</identifier><identifier>PMID: 19691485</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Aged ; Angioplasty, Balloon, Coronary - adverse effects ; Angioplasty, Balloon, Coronary - mortality ; Blood Platelets - pathology ; Cell Size ; Coronary Artery Disease - blood ; Coronary Artery Disease - mortality ; Coronary Artery Disease - therapy ; Coronary Restenosis - blood ; Coronary Restenosis - etiology ; Coronary Restenosis - mortality ; Female ; Humans ; Linear Models ; Male ; mean platelet volume ; meta‐analysis ; Middle Aged ; mortality ; myocardial infarction ; Myocardial Infarction - blood ; Myocardial Infarction - etiology ; Myocardial Infarction - mortality ; Odds Ratio ; Platelet Count ; Platelet Function Tests ; platelets ; Predictive Value of Tests ; Prognosis ; Risk Assessment ; Risk Factors</subject><ispartof>Journal of thrombosis and haemostasis, 2010-01, Vol.8 (1), p.148-156</ispartof><rights>2009 International Society on Thrombosis and Haemostasis</rights><rights>2009 International Society on Thrombosis and Haemostasis 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6254-e045ad07c3d9a4d515bda2e220a746a15f7f0f70f2360c45f97330af7d041df33</citedby><cites>FETCH-LOGICAL-c6254-e045ad07c3d9a4d515bda2e220a746a15f7f0f70f2360c45f97330af7d041df33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19691485$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHU, S. G.</creatorcontrib><creatorcontrib>BECKER, R. C.</creatorcontrib><creatorcontrib>BERGER, P. B.</creatorcontrib><creatorcontrib>BHATT, D. L.</creatorcontrib><creatorcontrib>EIKELBOOM, J. W.</creatorcontrib><creatorcontrib>KONKLE, B.</creatorcontrib><creatorcontrib>MOHLER, E. R.</creatorcontrib><creatorcontrib>REILLY, M. P.</creatorcontrib><creatorcontrib>BERGER, J. S.</creatorcontrib><title>Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta‐analysis</title><title>Journal of thrombosis and haemostasis</title><addtitle>J Thromb Haemost</addtitle><description>See also Machin SJ, Briggs C. Mean platelet volume: a quick, easy determinant of thrombotic risk? This issue, pp 146–7.
Summary. Aim:
To determine whether an association exists between mean platelet volume (MPV) and acute myocardial infarction (AMI) and other cardiovascular events. Platelet activity is a major culprit in atherothrombotic events. MPV, which is widely available in clinical practice, is a potentially useful biomarker of platelet activity in the setting of cardiovascular disease. Methods and Results: We performed a systematic review and meta‐analysis investigating the association between MPV and AMI, all‐cause mortality following myocardial infarction, and restenosis following coronary angioplasty. Results were pooled using random‐effects modeling. Pooled results from 16 cross‐sectional studies involving 2809 patients investigating the association of MPV and AMI indicated that MPV was significantly higher in those with AMI than those without AMI [mean difference 0.92 fL, 95% confidence interval (CI) 0.67–1.16, P < 0.001). In subgroup analyses, significant differences in MPV existed between subjects with AMI, subjects with stable coronary disease (P < 0.001), and stable controls (P < 0.001), but not vs. those with unstable angina (P = 0.24). Pooled results from three cohort studies involving 3184 patients evaluating the risk of death following AMI demonstrated that an elevated MPV increased the odds of death as compared with a normal MPV (11.5% vs. 7.1%, odds ratio 1.65, 95% CI 1.12–2.52, P = 0.012). Pooled results from five cohort studies involving 430 patients who underwent coronary angioplasty revealed that MPV was significantly higher in patients who developed restenosis than in those who did not develop restenosis (mean difference 0.98 fL, 95% CI 0.74–1.21, P < 0.001). Conclusions: Elevated MPV is associated with AMI, mortality following myocardial infarction, and restenosis following coronary angioplasty. These data suggest that MPV is a potentially useful prognostic biomarker in patients with cardiovascular disease. Whether the relationship is causal, and whether MPV should influence practice or guide therapy, remains unknown.</description><subject>Aged</subject><subject>Angioplasty, Balloon, Coronary - adverse effects</subject><subject>Angioplasty, Balloon, Coronary - mortality</subject><subject>Blood Platelets - pathology</subject><subject>Cell Size</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - mortality</subject><subject>Coronary Artery Disease - therapy</subject><subject>Coronary Restenosis - blood</subject><subject>Coronary Restenosis - etiology</subject><subject>Coronary Restenosis - mortality</subject><subject>Female</subject><subject>Humans</subject><subject>Linear Models</subject><subject>Male</subject><subject>mean platelet volume</subject><subject>meta‐analysis</subject><subject>Middle Aged</subject><subject>mortality</subject><subject>myocardial infarction</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - etiology</subject><subject>Myocardial Infarction - mortality</subject><subject>Odds Ratio</subject><subject>Platelet Count</subject><subject>Platelet Function Tests</subject><subject>platelets</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><issn>1538-7933</issn><issn>1538-7836</issn><issn>1538-7836</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9u1DAQhyMEoqXwCsgnOG3w3zhBAglVQEFFXMrZmtpj8OLEi51suzcegWfkSUjYpcAF4YtHmm9-Y-urKsJozebzZF0zJdqVbkVTc0q7mgrVyvr6VnV807j9q-6EOKrulbKmlHWK07vVEeuajslWHVf2HcJANhFGjDiSbYpTjwQKAbLJ6IIdUybJEwvZhbSFYqcImeRQPj-dmbIrI_YwBksybgNeERgc6XGE71-_wQBxV0K5X93xEAs-ONwn1YdXLy9Oz1bn71-_OX1xvrINV3KFVCpwVFvhOpBOMXXpgCPnFLRsgCmvPfWaei4aaqXynRaCgteOSua8ECfV833uZrrs0VkcxgzRbHLoIe9MgmD-7gzhk_mYtkZopWTXzAGPDwE5fZmwjKYPxWKMMGCaipn3KSkavqx69E-SMyE503QG2z1ocyolo795DqNmcWnWZtFkFmVmcWl-ujTX8-jDP7_ze_Agbwae7YGrEHH338Hm7cXZUokfFlSwdg</recordid><startdate>201001</startdate><enddate>201001</enddate><creator>CHU, S. G.</creator><creator>BECKER, R. C.</creator><creator>BERGER, P. B.</creator><creator>BHATT, D. L.</creator><creator>EIKELBOOM, J. W.</creator><creator>KONKLE, B.</creator><creator>MOHLER, E. R.</creator><creator>REILLY, M. P.</creator><creator>BERGER, J. S.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201001</creationdate><title>Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta‐analysis</title><author>CHU, S. G. ; BECKER, R. C. ; BERGER, P. B. ; BHATT, D. L. ; EIKELBOOM, J. W. ; KONKLE, B. ; MOHLER, E. R. ; REILLY, M. P. ; BERGER, J. S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6254-e045ad07c3d9a4d515bda2e220a746a15f7f0f70f2360c45f97330af7d041df33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Angioplasty, Balloon, Coronary - adverse effects</topic><topic>Angioplasty, Balloon, Coronary - mortality</topic><topic>Blood Platelets - pathology</topic><topic>Cell Size</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - mortality</topic><topic>Coronary Artery Disease - therapy</topic><topic>Coronary Restenosis - blood</topic><topic>Coronary Restenosis - etiology</topic><topic>Coronary Restenosis - mortality</topic><topic>Female</topic><topic>Humans</topic><topic>Linear Models</topic><topic>Male</topic><topic>mean platelet volume</topic><topic>meta‐analysis</topic><topic>Middle Aged</topic><topic>mortality</topic><topic>myocardial infarction</topic><topic>Myocardial Infarction - blood</topic><topic>Myocardial Infarction - etiology</topic><topic>Myocardial Infarction - mortality</topic><topic>Odds Ratio</topic><topic>Platelet Count</topic><topic>Platelet Function Tests</topic><topic>platelets</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHU, S. G.</creatorcontrib><creatorcontrib>BECKER, R. C.</creatorcontrib><creatorcontrib>BERGER, P. B.</creatorcontrib><creatorcontrib>BHATT, D. L.</creatorcontrib><creatorcontrib>EIKELBOOM, J. W.</creatorcontrib><creatorcontrib>KONKLE, B.</creatorcontrib><creatorcontrib>MOHLER, E. R.</creatorcontrib><creatorcontrib>REILLY, M. P.</creatorcontrib><creatorcontrib>BERGER, J. S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of thrombosis and haemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHU, S. G.</au><au>BECKER, R. C.</au><au>BERGER, P. B.</au><au>BHATT, D. L.</au><au>EIKELBOOM, J. W.</au><au>KONKLE, B.</au><au>MOHLER, E. R.</au><au>REILLY, M. P.</au><au>BERGER, J. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta‐analysis</atitle><jtitle>Journal of thrombosis and haemostasis</jtitle><addtitle>J Thromb Haemost</addtitle><date>2010-01</date><risdate>2010</risdate><volume>8</volume><issue>1</issue><spage>148</spage><epage>156</epage><pages>148-156</pages><issn>1538-7933</issn><issn>1538-7836</issn><eissn>1538-7836</eissn><abstract>See also Machin SJ, Briggs C. Mean platelet volume: a quick, easy determinant of thrombotic risk? This issue, pp 146–7.
Summary. Aim:
To determine whether an association exists between mean platelet volume (MPV) and acute myocardial infarction (AMI) and other cardiovascular events. Platelet activity is a major culprit in atherothrombotic events. MPV, which is widely available in clinical practice, is a potentially useful biomarker of platelet activity in the setting of cardiovascular disease. Methods and Results: We performed a systematic review and meta‐analysis investigating the association between MPV and AMI, all‐cause mortality following myocardial infarction, and restenosis following coronary angioplasty. Results were pooled using random‐effects modeling. Pooled results from 16 cross‐sectional studies involving 2809 patients investigating the association of MPV and AMI indicated that MPV was significantly higher in those with AMI than those without AMI [mean difference 0.92 fL, 95% confidence interval (CI) 0.67–1.16, P < 0.001). In subgroup analyses, significant differences in MPV existed between subjects with AMI, subjects with stable coronary disease (P < 0.001), and stable controls (P < 0.001), but not vs. those with unstable angina (P = 0.24). Pooled results from three cohort studies involving 3184 patients evaluating the risk of death following AMI demonstrated that an elevated MPV increased the odds of death as compared with a normal MPV (11.5% vs. 7.1%, odds ratio 1.65, 95% CI 1.12–2.52, P = 0.012). Pooled results from five cohort studies involving 430 patients who underwent coronary angioplasty revealed that MPV was significantly higher in patients who developed restenosis than in those who did not develop restenosis (mean difference 0.98 fL, 95% CI 0.74–1.21, P < 0.001). Conclusions: Elevated MPV is associated with AMI, mortality following myocardial infarction, and restenosis following coronary angioplasty. These data suggest that MPV is a potentially useful prognostic biomarker in patients with cardiovascular disease. Whether the relationship is causal, and whether MPV should influence practice or guide therapy, remains unknown.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19691485</pmid><doi>10.1111/j.1538-7836.2009.03584.x</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1538-7933 |
| ispartof | Journal of thrombosis and haemostasis, 2010-01, Vol.8 (1), p.148-156 |
| issn | 1538-7933 1538-7836 1538-7836 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3755496 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Aged Angioplasty, Balloon, Coronary - adverse effects Angioplasty, Balloon, Coronary - mortality Blood Platelets - pathology Cell Size Coronary Artery Disease - blood Coronary Artery Disease - mortality Coronary Artery Disease - therapy Coronary Restenosis - blood Coronary Restenosis - etiology Coronary Restenosis - mortality Female Humans Linear Models Male mean platelet volume meta‐analysis Middle Aged mortality myocardial infarction Myocardial Infarction - blood Myocardial Infarction - etiology Myocardial Infarction - mortality Odds Ratio Platelet Count Platelet Function Tests platelets Predictive Value of Tests Prognosis Risk Assessment Risk Factors |
| title | Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta‐analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T00%3A46%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mean%20platelet%20volume%20as%20a%20predictor%20of%20cardiovascular%20risk:%20a%20systematic%20review%20and%20meta%E2%80%90analysis&rft.jtitle=Journal%20of%20thrombosis%20and%20haemostasis&rft.au=CHU,%20S.%20G.&rft.date=2010-01&rft.volume=8&rft.issue=1&rft.spage=148&rft.epage=156&rft.pages=148-156&rft.issn=1538-7933&rft.eissn=1538-7836&rft_id=info:doi/10.1111/j.1538-7836.2009.03584.x&rft_dat=%3Cproquest_pubme%3E21342170%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=21342170&rft_id=info:pmid/19691485&rfr_iscdi=true |