Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta‐analysis

See also Machin SJ, Briggs C. Mean platelet volume: a quick, easy determinant of thrombotic risk? This issue, pp 146–7. Summary. Aim: To determine whether an association exists between mean platelet volume (MPV) and acute myocardial infarction (AMI) and other cardiovascular events. Platelet activity is a major culprit in atherothrombotic events. MPV, which is widely available in clinical practice, is a potentially useful biomarker of platelet activity in the setting of cardiovascular disease. Methods and Results: We performed a systematic review and meta‐analysis investigating the association between MPV and AMI, all‐cause mortality following myocardial infarction, and restenosis following coronary angioplasty. Results were pooled using random‐effects modeling. Pooled results from 16 cross‐sectional studies involving 2809 patients investigating the association of MPV and AMI indicated that MPV was significantly higher in those with AMI than those without AMI [mean difference 0.92 fL, 95% confidence interval (CI) 0.67–1.16, P