Plasma levels of cathepsins L, K, and V and risks of abdominal aortic aneurysms: A randomized population-based study

Abstract Background Cathepsin L (CatL), cathepsin K (CatK), and cathepsin V (CatV) are potent elastases implicated in human arterial wall remodeling. Whether plasma levels of these cathepsins are altered in patients with abdominal aortic aneurysms (AAAs) remains unknown. Methods and results Plasma s...

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Veröffentlicht in:	Atherosclerosis 2013-09, Vol.230 (1), p.100-105
Hauptverfasser:	Lv, Bing-Jie, Lindholt, Jes S, Wang, Jing, Cheng, Xiang, Shi, Guo-Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal aortic aneurysm Aged Ankle-brachial index Aorta - pathology Aortic Aneurysm, Abdominal - blood Aortic Aneurysm, Abdominal - epidemiology Aortic diameter aspirin atherosclerosis Body Mass Index Cardiovascular Case-Control Studies Cathepsin K Cathepsin K - blood Cathepsin L Cathepsin L - blood Cathepsin V Cathepsins - blood Cysteine Endopeptidases - blood Denmark - epidemiology Enzyme-Linked Immunosorbent Assay Gene Expression Regulation Humans Male odds ratio pathogenesis patients peptidyl-dipeptidase A Random Allocation regression analysis risk Risk Factors t-test
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Zusammenfassung:	Abstract Background Cathepsin L (CatL), cathepsin K (CatK), and cathepsin V (CatV) are potent elastases implicated in human arterial wall remodeling. Whether plasma levels of these cathepsins are altered in patients with abdominal aortic aneurysms (AAAs) remains unknown. Methods and results Plasma samples were collected from 476 male AAA patients and 200 age-matched male controls to determine CatL, CatK, and CatV levels by ELISA. Student's t -test demonstrated significantly higher plasma CatL levels in AAA patients than in controls ( P
ISSN:	0021-9150 1879-1484
DOI:	10.1016/j.atherosclerosis.2013.05.018