Prospects for oral replicating adenovirus-vectored vaccines

Highlights • Live oral adenovirus (Ad) vaccines have proven safe and effective. • Live recombinant Ads can express antigens as transgenes or by capsid display. • Ad recombinants are highly immunogenic. • Live Ad recombinants induce potent cell-mediated responses in permissive animals. • Capsid displ...

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Veröffentlicht in:	Vaccine 2013-07, Vol.31 (32), p.3236-3243
Hauptverfasser:	Deal, Cailin, Pekosz, Andrew, Ketner, Gary
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviridae - immunology Adenoviridae - physiology Adenovirus Administration, Oral Allergy and Immunology Animals Antigen presentation Antigens - genetics Antigens - immunology Applied microbiology Biological and medical sciences capsid Capsid - immunology Capsid Proteins - immunology Capsid-display Clinical trials Clinical Trials as Topic Disease epitopes Epitopes - immunology Fundamental and applied biological sciences. Psychology gene expression Genetic Vectors Genomes Hexon Humans Immune system Immunity, Cellular Immunity, Humoral Immunization Immunology Infections Infectious diseases Influenza Malaria Microbiology Miscellaneous Monkeys & apes Oral administration Proteins Replicating adenovirus vectors Rodents serotypes Studies Transgenes vaccination Vaccine Vaccines Vaccines - genetics Vaccines - immunology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Synthetic - immunology Virology Virus Replication
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Beschreibung
Zusammenfassung:	Highlights • Live oral adenovirus (Ad) vaccines have proven safe and effective. • Live recombinant Ads can express antigens as transgenes or by capsid display. • Ad recombinants are highly immunogenic. • Live Ad recombinants induce potent cell-mediated responses in permissive animals. • Capsid display recombinants promise good humoral responses.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.05.016