Effect of Losartan on Prevention and Progression of Early Diabetic Nephropathy in American Indians With Type 2 Diabetes

Angiotensin receptor blockers are renoprotective in hypertensive azotemic patients with type 2 diabetes, but their efficacy in early diabetic kidney disease is uncertain. We performed a 6-year randomized clinical trial in 169 American Indians with type 2 diabetes and normoalbuminuria (albumin/creati...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2013-09, Vol.62 (9), p.3224-3231
Hauptverfasser:	JENNIFER WEIL, E, FUFAA, Gudeta, NELSON, Robert G, JONES, Lois I, LOVATO, Tracy, LEMLEY, Kevin V, HANSON, Robert L, KNOWLER, William C, BENNETT, Peter H, YEE, Berne, MYERS, Bryan D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Associated diseases and complications Biological and medical sciences Clinical trials Complications and side effects Development and progression Diabetes Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy Diabetes. Impaired glucose tolerance Diabetic nephropathies Diabetic Nephropathies - drug therapy Diabetic Nephropathies - prevention & control Dosage and administration Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Humans Indians, North American Kidney diseases Kidneys Losartan Losartan - therapeutic use Male Medical sciences Middle Aged Native North Americans Nephrology. Urinary tract diseases Original Research Prevention Risk factors Side effects Type 2 diabetes Urinary system involvement in other diseases. Miscellaneous Young Adult
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Zusammenfassung:	Angiotensin receptor blockers are renoprotective in hypertensive azotemic patients with type 2 diabetes, but their efficacy in early diabetic kidney disease is uncertain. We performed a 6-year randomized clinical trial in 169 American Indians with type 2 diabetes and normoalbuminuria (albumin/creatinine ratio [ACR]
ISSN:	0012-1797 1939-327X
DOI:	10.2337/db12-1512