Effect of methysergide on pudendal inhibition of micturition reflex in cats

The role of 5-HT2 and opioid receptors in pudendal inhibition of bladder activity induced by intravesical infusion of saline or 0.25% acetic acid (AA) was investigated in anesthetized cats using methysergide (a 5-HT2 receptor antagonist) and naloxone (an opioid receptor antagonist). AA irritated the...

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Veröffentlicht in:	Experimental neurology 2013-09, Vol.247, p.250-258
Hauptverfasser:	Matsuta, Yosuke, Schwen, Zeyad, Mally, Abhijith D., Shen, Bing, Wang, Jicheng, Roppolo, James R., de Groat, William C., Tai, Changfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT2 receptor Acetic Acid - pharmacology Analysis of Variance Animals Biological and medical sciences Biophysics Cat Cats Dose-Response Relationship, Drug Electric Stimulation Female Male Medical sciences Methysergide - pharmacology Naloxone - pharmacology Narcotic Antagonists - pharmacology Neurology Neuromodulation Neuropharmacology Neuroprotective agent Opioid receptor Pharmacology. Drug treatments Piperazines - pharmacology Pudendal Pudendal Nerve - drug effects Pudendal Nerve - physiology Pyridines - pharmacology Reflex - drug effects Reflex - physiology Serotonin Antagonists - pharmacology Urinary Bladder - drug effects Urinary Bladder - innervation Urinary Bladder - physiology Urination - drug effects Urination - physiology
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Zusammenfassung:	The role of 5-HT2 and opioid receptors in pudendal inhibition of bladder activity induced by intravesical infusion of saline or 0.25% acetic acid (AA) was investigated in anesthetized cats using methysergide (a 5-HT2 receptor antagonist) and naloxone (an opioid receptor antagonist). AA irritated the bladder and significantly (P
ISSN:	0014-4886 1090-2430
DOI:	10.1016/j.expneurol.2013.05.006