Directed Amination of Non-Acidic Arene CH Bonds by a Copper-Silver Catalytic System

Directed Amination of Non-Acidic Arene CH Bonds by a Copper-Silver Catalytic System

Amine meets arene: A method for direct amination of β‐C(sp2)H bonds of benzoic acid derivatives and γ‐C(sp2)H bonds of benzylamine derivatives has been developed. The reaction is catalyzed by Cu(OAc)2 and a Ag2CO3 cocatalyst, and shows high generality and functional‐group tolerance, as well as pro...

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Veröffentlicht in:Angewandte Chemie International Edition 2013-06, Vol.52 (23), p.6043-6046
Hauptverfasser: Tran, Ly Dieu, Roane, James, Daugulis, Olafs
Format: Artikel
Sprache:eng
Schlagworte:
amination
Amines
arenes
Aromatic compounds
Benzoic acid
Catalysis
Catalysts
copper
CH activation
Derivatives
Tolerances
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Zusammenfassung:Amine meets arene: A method for direct amination of β‐C(sp2)H bonds of benzoic acid derivatives and γ‐C(sp2)H bonds of benzylamine derivatives has been developed. The reaction is catalyzed by Cu(OAc)2 and a Ag2CO3 cocatalyst, and shows high generality and functional‐group tolerance, as well as providing a straightforward means for the preparation of ortho‐aminobenzoic acid derivatives.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201300135