Basophils help establish protective immunity induced by irradiated larval vaccination for filariasis

Highlights • Basophils help establish protective immunity induced by irradiated larval vaccination for filariasis. • Basophil depletion attenuates protective efficacy of irradiated L3 vaccination in filariasis. • Basophil depletion decreases both IgE and cellular immune responses induced by irradiat...

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Veröffentlicht in:	Vaccine 2013-08, Vol.31 (36), p.3675-3682
Hauptverfasser:	Torrero, Marina N, Morris, C. Paul, Mitre, Blima K, Hübner, Marc P, Fox, Ellen M, Karasuyama, Hajime, Mitre, Edward
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergies Allergy and Immunology Animals Antibodies Antibodies, Helminth - blood Antibodies, Monoclonal - administration & dosage Antigens Applied microbiology Basophil basophils Basophils - immunology Biological and medical sciences blindness CD4-positive T-lymphocytes CD4-Positive T-Lymphocytes - immunology cell-mediated immunity Cytokines Diseases caused by nematodes Female Filariases Filariasis Filariasis - immunology Filariasis - prevention & control Filarioidea - immunology Filarioidea - radiation effects Fundamental and applied biological sciences. Psychology Helminth Helminthic diseases helminths Immune response Immunity, Cellular Immunoglobulin E - blood Infections Infectious diseases interferon-gamma Interferon-gamma - immunology interleukin-10 interleukin-4 interleukin-5 Interleukins - immunology Larva - immunology Larva - radiation effects Larvae Litomosoides sigmodontis Lymphatic filariases Lymphocyte Depletion Mast Cells - immunology Medical research Medical sciences Mice Mice, Inbred BALB C Microbiology Nematoda Parasites Parasitic diseases protective effect rivers Rodents Studies Tropical diseases Type 2 immunity vaccination Vaccine Vaccines Vaccines - immunology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Zusammenfassung:	Highlights • Basophils help establish protective immunity induced by irradiated larval vaccination for filariasis. • Basophil depletion attenuates protective efficacy of irradiated L3 vaccination in filariasis. • Basophil depletion decreases both IgE and cellular immune responses induced by irradiated L3 vaccination.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.06.010