The CXXC-TET bridge - mind the methylation gap

CG-rich DNA ＂reader＂ proteins that bind non-methylated CpG sequences have emerged as critical factors to the process of cell differen- tiation and development. In a recent paper in Nature, Ko et al. show that the CXXC domain protein, IDAX, plays a crucial role as a CG-rich DNA-binding factor in the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell research 2013-08, Vol.23 (8), p.973-974
Hauptverfasser:	Dunican, Donncha S, Pennings, Sari, Meehan, Richard R
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methylcytosine - metabolism 631/208/176/1988 631/208/200 Animals Biomedical and Life Sciences Cell Biology Cell differentiation CpG序列 C结构域 Deoxyribonucleic acid DNA DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism Humans Life Sciences Proto-Oncogene Proteins - metabolism Research Highlight TET Transcription Factors - chemistry Transcription Factors - metabolism Translocation 差距甲基化细胞分化结合因子蛋白质结合
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	CG-rich DNA ＂reader＂ proteins that bind non-methylated CpG sequences have emerged as critical factors to the process of cell differen- tiation and development. In a recent paper in Nature, Ko et al. show that the CXXC domain protein, IDAX, plays a crucial role as a CG-rich DNA-binding factor in the regula- tion of Ten-Eleven-Translocation 2 （TET2） protein function.
ISSN:	1001-0602 1748-7838
DOI:	10.1038/cr.2013.71