Stem cell competition: finding balance in the niche

Stem cell competition: finding balance in the niche

Highlights • Genetically equal stem cells compete for niche occupancy in multiple tissues. • Stochastic competition for niche access is important for stem cell fitness. • Mutated stem cells can gain a competitive advantage or disadvantage. • Stem cells with a competitive advantage can cause diseases...

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Veröffentlicht in:Trends in cell biology 2013-08, Vol.23 (8), p.357-364
Hauptverfasser: Stine, Rachel R, Matunis, Erika L
Format: Artikel
Sprache:eng
Schlagworte:
Animals
cancer
competition
Drosophila melanogaster - cytology
Hematopoiesis
Mammals - metabolism
niche
Organ Specificity
Pathology
stem cell
Stem Cell Niche
Stem Cells - cytology
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Beschreibung
Zusammenfassung:Highlights • Genetically equal stem cells compete for niche occupancy in multiple tissues. • Stochastic competition for niche access is important for stem cell fitness. • Mutated stem cells can gain a competitive advantage or disadvantage. • Stem cells with a competitive advantage can cause diseases or niche defects.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2013.03.001