Midtrimester amniotic fluid matrix metalloproteinase-8 (MMP-8) levels above the 90th percentile are a marker for subsequent preterm premature rupture of membranes

We sought to determine whether midtrimester amniotic fluid levels of matrix metalloproteinase-8 were associated with subsequent preterm premature rupture of membranes. We conducted a case-control study examining 57 asymptomatic women who underwent genetic amniocentesis from 14 to 21 weeks' gest...

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Veröffentlicht in:	American journal of obstetrics and gynecology 2005, Vol.192 (1), p.109-113
Hauptverfasser:	Biggio, Joseph R., Ramsey, Patrick S., Cliver, Suzanne P., Lyon, Martha D., Goldenberg, Robert L., Wenstrom, Katharine D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amniotic Fluid - metabolism Biological and medical sciences Biomarkers - metabolism Case-Control Studies Delivery. Postpartum. Lactation Diseases of mother, fetus and pregnancy Disorders Enzyme-Linked Immunosorbent Assay Female Fetal Membranes, Premature Rupture - diagnosis Fetal Membranes, Premature Rupture - metabolism Gynecology. Andrology. Obstetrics Humans Intrauterine inflammation Matrix Metalloproteinase 8 - metabolism Matrix metalloproteinase-8 Medical sciences Predictive Value of Tests Pregnancy Pregnancy Trimester, Second Pregnancy. Fetus. Placenta Premature rupture of membranes Preterm birth ROC Curve Sensitivity and Specificity
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Zusammenfassung:	We sought to determine whether midtrimester amniotic fluid levels of matrix metalloproteinase-8 were associated with subsequent preterm premature rupture of membranes. We conducted a case-control study examining 57 asymptomatic women who underwent genetic amniocentesis from 14 to 21 weeks' gestation and subsequently had preterm premature rupture of membranes (
ISSN:	0002-9378 1097-6868
DOI:	10.1016/j.ajog.2004.06.103