Peripheral blood HIV DNA is associated with atrophy of cerebellar and subcortical gray matter

OBJECTIVE:We evaluated regional brain volumes and cerebral metabolite levels as correlates of HIV DNA in peripheral blood mononuclear cells (PBMCs). METHODS:In this cross-sectional study, 35 HIV+ subjects aged ≥40 years (25 with detectable PBMC HIV DNA; 10 with HIV DNA

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Bibliographische Detailangaben
Veröffentlicht in:	Neurology 2013-05, Vol.80 (19), p.1792-1799
Hauptverfasser:	Kallianpur, Kalpana J, Shikuma, Cecilia, Kirk, Gregory R, Shiramizu, Bruce, Valcour, Victor, Chow, Dominic, Souza, Scott, Nakamoto, Beau, Sailasuta, Napapon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Atrophy Biological and medical sciences Cerebellum - pathology Cerebellum - virology Cerebral Cortex - pathology Cerebral Cortex - virology Cross-Sectional Studies DNA, Viral - blood Female HIV Infections - blood HIV Infections - diagnosis HIV Infections - pathology HIV Seropositivity - diagnosis HIV Seropositivity - epidemiology HIV Seropositivity - pathology Human immunodeficiency virus Human viral diseases Humans Infectious diseases Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Medical sciences Middle Aged Neurology Pilot Projects Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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Beschreibung
Zusammenfassung:	OBJECTIVE:We evaluated regional brain volumes and cerebral metabolite levels as correlates of HIV DNA in peripheral blood mononuclear cells (PBMCs). METHODS:In this cross-sectional study, 35 HIV+ subjects aged ≥40 years (25 with detectable PBMC HIV DNA; 10 with HIV DNA
ISSN:	0028-3878 1526-632X
DOI:	10.1212/WNL.0b013e318291903f