Does high-density lipoprotein influence the development of saphenous vein graft disease after coronary bypass surgery?: exploratory analysis from the CASCADE trial

Low levels of high-density lipoprotein (HDL) purportedly increase the risk after coronary bypass surgery. This may relate to the development of saphenous vein graft (SVG) disease early postoperatively, but this premise has never been evaluated in the context of a prospective trial. The CASCADE Trial...

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Veröffentlicht in:Journal of cardiothoracic surgery 2013-07, Vol.8 (1), p.172-172, Article 172
Hauptverfasser: Jerzewski, Katie, Ruel, Marc, Voisine, Pierre, Le May, Michel R, Kulik, Alexander
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Sprache:eng
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Zusammenfassung:Low levels of high-density lipoprotein (HDL) purportedly increase the risk after coronary bypass surgery. This may relate to the development of saphenous vein graft (SVG) disease early postoperatively, but this premise has never been evaluated in the context of a prospective trial. The CASCADE Trial was a multi-center study of 113 patients evaluating the use of postoperative clopidogrel. Patients received standard lipid management after surgery (96% statins). At 12 months, angiography and intravascular ultrasound was performed to assess SVG occlusion and intimal hyperplasia, respectively. In this exploratory analysis, we evaluated the influence of HDL levels on the development of SVG disease at 12 months, using the established cut-off of
ISSN:1749-8090
1749-8090
DOI:10.1186/1749-8090-8-172