Inhibition of neutral endopeptidase potentiates neutrophil activation during Mg-deficiency in the rat

. Neutral endopeptidase (NEP), which degrades substance P (SP), may regulate neutrophil activation during Mg-deficiency (MgD). Male Sprague-Dawley rats (180g) were fed MgD (~50 mg Mg/kg) or Mg-sufficient (MgS, 608 mg Mg/kg) diets for 7 days ± NEP inhibitor phosphoramidon (PR, 5 mg/kg/day, s.c.). MgD...

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Veröffentlicht in:	Inflammation research 2008-07, Vol.57 (7), p.300-305
Hauptverfasser:	Mak, I. T., Kramer, J. H., Chmielinska, J. J., Khalid, M. H., Landgraf, K. M., Weglicki, W. B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergology Animals Biomedical and Life Sciences Biomedicine Cells, Cultured Dermatology Enzyme Activation Enzyme Inhibitors - pharmacology Glutathione - chemistry Immunology Magnesium - chemistry Male Neprilysin - antagonists & inhibitors Neprilysin - chemistry Neurology Neutrophils - cytology Neutrophils - metabolism Oxidative Stress Pharmacology/Toxicology Rats Rats, Sprague-Dawley Reactive Oxygen Species Rheumatology Short Communication Substance P - metabolism
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Zusammenfassung:	. Neutral endopeptidase (NEP), which degrades substance P (SP), may regulate neutrophil activation during Mg-deficiency (MgD). Male Sprague-Dawley rats (180g) were fed MgD (~50 mg Mg/kg) or Mg-sufficient (MgS, 608 mg Mg/kg) diets for 7 days ± NEP inhibitor phosphoramidon (PR, 5 mg/kg/day, s.c.). MgD alone induced a 9-fold (vs. MgS, p
ISSN:	1023-3830 1420-908X
DOI:	10.1007/s00011-007-7186-z