Trefoil factor 3 overexpression in prostatic carcinoma: Prognostic importance using tissue microarrays

Trefoil factor 3 overexpression in prostatic carcinoma: Prognostic importance using tissue microarrays

BACKGROUND Human intestinal trefoil factor 3 (TFF3) is a member of a family of polypeptides encoded by a cluster of genes on chromosome 21. Through gene expression profiling studies TFF3 mRNA has been found to be overexpressed in prostate cancer. METHODS We used immunochemistry on tissue microarrays...

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Veröffentlicht in:The Prostate 2004-11, Vol.61 (3), p.215-227
Hauptverfasser: Faith, Dennis A., Isaacs, William B., Morgan, James D., Fedor, Helen L., Hicks, Jessica L., Mangold, Leslie A., Walsh, Patrick C., Partin, Alan W., Platz, Elizabeth A., Luo, Jun, De Marzo, Angelo M.
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Biomarkers, Tumor
Blotting, Western
Bone Neoplasms - secondary
Gynecology. Andrology. Obstetrics
Humans
Immunohistochemistry
Lymphatic Metastasis
Male
Male genital diseases
Medical sciences
Mucins - metabolism
Muscle Proteins - metabolism
Nephrology. Urinary tract diseases
Peptides
Prognosis
prostate cancer
Prostatectomy
Prostatic Neoplasms - metabolism
Prostatic Neoplasms - pathology
Prostatic Neoplasms - surgery
Soft Tissue Neoplasms - secondary
tissue microarrays
trefoil factor
Trefoil Factor-3
Tumors
Tumors of the urinary system
Urinary tract. Prostate gland
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Zusammenfassung:BACKGROUND Human intestinal trefoil factor 3 (TFF3) is a member of a family of polypeptides encoded by a cluster of genes on chromosome 21. Through gene expression profiling studies TFF3 mRNA has been found to be overexpressed in prostate cancer. METHODS We used immunochemistry on tissue microarrays and software tools, collectively referred to as TMAJ, for online assessment of staining to analyze samples from 294 primary tumors and 61 metastatic lesions. RESULTS Applying a cutoff of 20% of cells staining as positive, the frequency of staining was 18.8% in normal (51 of 272) and 47.0% in primary tumors (126 of 268), P 
ISSN:0270-4137
1097-0045
DOI:10.1002/pros.20095