Fetal sex-related dysregulation in testosterone production and their receptor expression in the human placenta with preeclampsia

Objective: To determine the effects of fetal sex on aromatase and androgen receptor (AR) expression in the placenta of normal and preeclamptic pregnancies. Study Design: Placentae from preeclamptic (five female and six male fetuses) and healthy pregnancies (seven female and seven male fetuses) were...

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Veröffentlicht in:	Journal of perinatology 2012-05, Vol.32 (5), p.328-335
Hauptverfasser:	Sathishkumar, K, Balakrishnan, M, Chinnathambi, V, Chauhan, M, Hankins, G D V, Yallampalli, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Androgen receptors Androgens Angiogenesis Antibodies Aromatase Blotting, Western Care and treatment Case-Control Studies Complications Diabetes Diagnosis Female Fetuses Gender differences Gene Expression Regulation, Developmental Gestational Age Gynecology Health aspects Hormone receptors Hormones Humans Hypertension Immunofluorescence Immunohistochemistry Infant, Newborn Male Males Medicine Medicine & Public Health Multivariate Analysis Obstetrics original-article Pediatric Surgery Pediatrics Physiological aspects Pilot Projects Placenta Placenta - metabolism Placenta - pathology Pre-eclampsia Pre-Eclampsia - diagnosis Pre-Eclampsia - genetics Pre-Eclampsia - metabolism Preeclampsia Pregnancy Pregnancy - physiology Properties Receptors Receptors, Androgen - genetics Receptors, Androgen - metabolism Reference Values Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - metabolism RNA-directed DNA polymerase Sex Sex Characteristics Signal Transduction - genetics Testosterone Testosterone - analysis Testosterone - biosynthesis Western blotting Womens health
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Beschreibung
Zusammenfassung:	Objective: To determine the effects of fetal sex on aromatase and androgen receptor (AR) expression in the placenta of normal and preeclamptic pregnancies. Study Design: Placentae from preeclamptic (five female and six male fetuses) and healthy pregnancies (seven female and seven male fetuses) were examined by immunofluorescence, western blotting and quantitative reverse transcriptase PCR. Result: Placental AR levels were significantly higher ( P
ISSN:	0743-8346 1476-5543
DOI:	10.1038/jp.2011.101