Does thyroid-stimulating hormone influence the prognosis of patients with endometrial cancer? A multicentre trial

Background: Thyroid function has been suggested to interfere with tumour biology and prognosis in different cancers. The present study was performed to investigate the impact of pre-therapeutic serum thyroid-stimulating hormone (TSH) levels on the prognosis of patients with endometrial cancer. Methods: Pre-therapeutic serum TSH was investigated in 199 patients with endometrial cancer. After stratification in TSH risk groups, univariate and multivariable survival analyses were performed. Results: Elevated TSH was independently associated with poor disease-specific survival in univariate/multivariable survival analyses ( P =0.01 and P =0.03, respectively). Conclusion: Thyroid-stimulating hormone may serve as a novel and independent prognostic parameter for disease-specific survival in patients with endometrial cancer.