Effector-like CD8+ T Cells in the Memory Population Mediate Potent Protective Immunity
The CD8+ memory T cell population is heterogeneous, and it is unclear which subset(s) optimally mediate the central goal of the immune system—protection against infection. Here we investigate the protective capacities of CD8+ T cell subsets present at the memory stage of the immune response. We show...
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| Veröffentlicht in: | Immunity (Cambridge, Mass.) Mass.), 2013-06, Vol.38 (6), p.1250-1260 |
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| creator | Olson, Janelle A. McDonald-Hyman, Cameron Jameson, Stephen C. Hamilton, Sara E. |
| description | The CD8+ memory T cell population is heterogeneous, and it is unclear which subset(s) optimally mediate the central goal of the immune system—protection against infection. Here we investigate the protective capacities of CD8+ T cell subsets present at the memory stage of the immune response. We show that a population of CD8+ T cells bearing markers associated with effector cells (KLRG1hi, CD27lo, T-bethi, Eomeslo) persisted to the memory phase and provided optimal control of Listeria monocytogenes and vaccinia virus, despite weak recall proliferative responses. After antigen-specific boosting, this population formed the predominant secondary memory subset and maintained superior pathogen control. The effector-like memory subset displayed a distinct pattern of tissue distribution and localization within the spleen, and their enhanced capacity to eliminate Listeria involved specialized utilization of cytolysis. Together, these data suggest that long-lived effector CD8+ T cells are optimal for protective immunity against certain pathogens.
•Effector-like CD27lo CD8+ T cells persist into primary and secondary memory pools•Despite weak expansion, “long-lived effectors” optimally control Listeria and vaccinia•CD27lo memory CD8+ cells show tissue localization favoring rapid pathogen encounter•Cytolysis is selectively utilized by CD27lo memory cells for Listeria control |
| doi_str_mv | 10.1016/j.immuni.2013.05.009 |
| format | Article |
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•Effector-like CD27lo CD8+ T cells persist into primary and secondary memory pools•Despite weak expansion, “long-lived effectors” optimally control Listeria and vaccinia•CD27lo memory CD8+ cells show tissue localization favoring rapid pathogen encounter•Cytolysis is selectively utilized by CD27lo memory cells for Listeria control</description><identifier>ISSN: 1074-7613</identifier><identifier>EISSN: 1097-4180</identifier><identifier>DOI: 10.1016/j.immuni.2013.05.009</identifier><identifier>PMID: 23746652</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Antigens ; CD8-Positive T-Lymphocytes - immunology ; CD8-Positive T-Lymphocytes - microbiology ; CD8-Positive T-Lymphocytes - virology ; Cells, Cultured ; Cytokines ; Cytotoxicity, Immunologic ; Female ; Genotype & phenotype ; Immunity, Active ; Immunologic Memory ; Infections ; Laboratories ; Lectins, C-Type - metabolism ; Listeria ; Listeria monocytogenes ; Listeria monocytogenes - immunology ; Listeriosis - immunology ; Lymphocytes ; Mice ; Mice, Inbred C57BL ; Poxviridae Infections - immunology ; T-Box Domain Proteins - metabolism ; T-Lymphocyte Subsets - immunology ; T-Lymphocyte Subsets - microbiology ; T-Lymphocyte Subsets - virology ; Trans-Activators - metabolism ; Tumor Necrosis Factor Receptor Superfamily, Member 7 - metabolism ; Vaccinia virus ; Vaccinia virus - immunology</subject><ispartof>Immunity (Cambridge, Mass.), 2013-06, Vol.38 (6), p.1250-1260</ispartof><rights>2013 Elsevier Inc.</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Jun 27, 2013</rights><rights>2013 Elsevier Inc. All rights reserved. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c524t-caa41e4cf5e26ab0157484c5255aec4a596156df17997e4e21c4b85dcab0b8b3</citedby><cites>FETCH-LOGICAL-c524t-caa41e4cf5e26ab0157484c5255aec4a596156df17997e4e21c4b85dcab0b8b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.immuni.2013.05.009$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23746652$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Olson, Janelle A.</creatorcontrib><creatorcontrib>McDonald-Hyman, Cameron</creatorcontrib><creatorcontrib>Jameson, Stephen C.</creatorcontrib><creatorcontrib>Hamilton, Sara E.</creatorcontrib><title>Effector-like CD8+ T Cells in the Memory Population Mediate Potent Protective Immunity</title><title>Immunity (Cambridge, Mass.)</title><addtitle>Immunity</addtitle><description>The CD8+ memory T cell population is heterogeneous, and it is unclear which subset(s) optimally mediate the central goal of the immune system—protection against infection. Here we investigate the protective capacities of CD8+ T cell subsets present at the memory stage of the immune response. We show that a population of CD8+ T cells bearing markers associated with effector cells (KLRG1hi, CD27lo, T-bethi, Eomeslo) persisted to the memory phase and provided optimal control of Listeria monocytogenes and vaccinia virus, despite weak recall proliferative responses. After antigen-specific boosting, this population formed the predominant secondary memory subset and maintained superior pathogen control. The effector-like memory subset displayed a distinct pattern of tissue distribution and localization within the spleen, and their enhanced capacity to eliminate Listeria involved specialized utilization of cytolysis. Together, these data suggest that long-lived effector CD8+ T cells are optimal for protective immunity against certain pathogens.
•Effector-like CD27lo CD8+ T cells persist into primary and secondary memory pools•Despite weak expansion, “long-lived effectors” optimally control Listeria and vaccinia•CD27lo memory CD8+ cells show tissue localization favoring rapid pathogen encounter•Cytolysis is selectively utilized by CD27lo memory cells for Listeria control</description><subject>Animals</subject><subject>Antigens</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>CD8-Positive T-Lymphocytes - microbiology</subject><subject>CD8-Positive T-Lymphocytes - virology</subject><subject>Cells, Cultured</subject><subject>Cytokines</subject><subject>Cytotoxicity, Immunologic</subject><subject>Female</subject><subject>Genotype & phenotype</subject><subject>Immunity, Active</subject><subject>Immunologic Memory</subject><subject>Infections</subject><subject>Laboratories</subject><subject>Lectins, C-Type - metabolism</subject><subject>Listeria</subject><subject>Listeria monocytogenes</subject><subject>Listeria monocytogenes - immunology</subject><subject>Listeriosis - immunology</subject><subject>Lymphocytes</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Poxviridae Infections - immunology</subject><subject>T-Box Domain Proteins - metabolism</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>T-Lymphocyte Subsets - microbiology</subject><subject>T-Lymphocyte Subsets - virology</subject><subject>Trans-Activators - metabolism</subject><subject>Tumor Necrosis Factor Receptor Superfamily, Member 7 - metabolism</subject><subject>Vaccinia virus</subject><subject>Vaccinia virus - immunology</subject><issn>1074-7613</issn><issn>1097-4180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1v1DAQjRCIlsI_QMgSFySUYMdjO7kgVUuBSkX0sOJqOc6EeknixXZW2n-Pt1vKxwFOY828eX7zXlE8Z7RilMk3m8pN0zK7qqaMV1RUlLYPilNGW1UCa-jDw1tBqSTjJ8WTGDeUMhAtfVyc1FyBlKI-Lb5cDAPa5EM5um9IVu-a12RNVjiOkbiZpBskn3DyYU-u_XYZTXJ-zp3emYS5lXBO5DrkapPbIbm8lZT2T4tHgxkjPrurZ8X6_cV69bG8-vzhcnV-VVpRQyqtMcAQ7CCwlqajTChoIM-EMGjBiFYyIfuBqbZVCFgzC10jepuxXdPxs-LtkXa7dBP2NqsJZtTb4CYT9tobp_-czO5Gf_U7zRXltYBM8OqOIPjvC8akJxdtvt7M6JeomRQgD141_4dyxYGDZHWGvvwLuvFLmLMRmRBAcVnfEsIRZYOPMeBwr5tRfYhYb_QxYn2IWFOhc8R57cXvN98v_cz0lymYjd85DDpah7PNoYUck-69-_cPPwB9mblO</recordid><startdate>20130627</startdate><enddate>20130627</enddate><creator>Olson, Janelle A.</creator><creator>McDonald-Hyman, Cameron</creator><creator>Jameson, Stephen C.</creator><creator>Hamilton, Sara E.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130627</creationdate><title>Effector-like CD8+ T Cells in the Memory Population Mediate Potent Protective Immunity</title><author>Olson, Janelle A. ; McDonald-Hyman, Cameron ; Jameson, Stephen C. ; Hamilton, Sara E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c524t-caa41e4cf5e26ab0157484c5255aec4a596156df17997e4e21c4b85dcab0b8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Antigens</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>CD8-Positive T-Lymphocytes - microbiology</topic><topic>CD8-Positive T-Lymphocytes - virology</topic><topic>Cells, Cultured</topic><topic>Cytokines</topic><topic>Cytotoxicity, Immunologic</topic><topic>Female</topic><topic>Genotype & phenotype</topic><topic>Immunity, Active</topic><topic>Immunologic Memory</topic><topic>Infections</topic><topic>Laboratories</topic><topic>Lectins, C-Type - metabolism</topic><topic>Listeria</topic><topic>Listeria monocytogenes</topic><topic>Listeria monocytogenes - immunology</topic><topic>Listeriosis - immunology</topic><topic>Lymphocytes</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Poxviridae Infections - immunology</topic><topic>T-Box Domain Proteins - metabolism</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>T-Lymphocyte Subsets - microbiology</topic><topic>T-Lymphocyte Subsets - virology</topic><topic>Trans-Activators - metabolism</topic><topic>Tumor Necrosis Factor Receptor Superfamily, Member 7 - metabolism</topic><topic>Vaccinia virus</topic><topic>Vaccinia virus - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Olson, Janelle A.</creatorcontrib><creatorcontrib>McDonald-Hyman, Cameron</creatorcontrib><creatorcontrib>Jameson, Stephen C.</creatorcontrib><creatorcontrib>Hamilton, Sara E.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Immunity (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Olson, Janelle A.</au><au>McDonald-Hyman, Cameron</au><au>Jameson, Stephen C.</au><au>Hamilton, Sara E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effector-like CD8+ T Cells in the Memory Population Mediate Potent Protective Immunity</atitle><jtitle>Immunity (Cambridge, Mass.)</jtitle><addtitle>Immunity</addtitle><date>2013-06-27</date><risdate>2013</risdate><volume>38</volume><issue>6</issue><spage>1250</spage><epage>1260</epage><pages>1250-1260</pages><issn>1074-7613</issn><eissn>1097-4180</eissn><abstract>The CD8+ memory T cell population is heterogeneous, and it is unclear which subset(s) optimally mediate the central goal of the immune system—protection against infection. Here we investigate the protective capacities of CD8+ T cell subsets present at the memory stage of the immune response. We show that a population of CD8+ T cells bearing markers associated with effector cells (KLRG1hi, CD27lo, T-bethi, Eomeslo) persisted to the memory phase and provided optimal control of Listeria monocytogenes and vaccinia virus, despite weak recall proliferative responses. After antigen-specific boosting, this population formed the predominant secondary memory subset and maintained superior pathogen control. The effector-like memory subset displayed a distinct pattern of tissue distribution and localization within the spleen, and their enhanced capacity to eliminate Listeria involved specialized utilization of cytolysis. Together, these data suggest that long-lived effector CD8+ T cells are optimal for protective immunity against certain pathogens.
•Effector-like CD27lo CD8+ T cells persist into primary and secondary memory pools•Despite weak expansion, “long-lived effectors” optimally control Listeria and vaccinia•CD27lo memory CD8+ cells show tissue localization favoring rapid pathogen encounter•Cytolysis is selectively utilized by CD27lo memory cells for Listeria control</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23746652</pmid><doi>10.1016/j.immuni.2013.05.009</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antigens CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - microbiology CD8-Positive T-Lymphocytes - virology Cells, Cultured Cytokines Cytotoxicity, Immunologic Female Genotype & phenotype Immunity, Active Immunologic Memory Infections Laboratories Lectins, C-Type - metabolism Listeria Listeria monocytogenes Listeria monocytogenes - immunology Listeriosis - immunology Lymphocytes Mice Mice, Inbred C57BL Poxviridae Infections - immunology T-Box Domain Proteins - metabolism T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - microbiology T-Lymphocyte Subsets - virology Trans-Activators - metabolism Tumor Necrosis Factor Receptor Superfamily, Member 7 - metabolism Vaccinia virus Vaccinia virus - immunology |
| title | Effector-like CD8+ T Cells in the Memory Population Mediate Potent Protective Immunity |
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