Effector-like CD8+ T Cells in the Memory Population Mediate Potent Protective Immunity
The CD8+ memory T cell population is heterogeneous, and it is unclear which subset(s) optimally mediate the central goal of the immune system—protection against infection. Here we investigate the protective capacities of CD8+ T cell subsets present at the memory stage of the immune response. We show...
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Veröffentlicht in: | Immunity (Cambridge, Mass.) Mass.), 2013-06, Vol.38 (6), p.1250-1260 |
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Zusammenfassung: | The CD8+ memory T cell population is heterogeneous, and it is unclear which subset(s) optimally mediate the central goal of the immune system—protection against infection. Here we investigate the protective capacities of CD8+ T cell subsets present at the memory stage of the immune response. We show that a population of CD8+ T cells bearing markers associated with effector cells (KLRG1hi, CD27lo, T-bethi, Eomeslo) persisted to the memory phase and provided optimal control of Listeria monocytogenes and vaccinia virus, despite weak recall proliferative responses. After antigen-specific boosting, this population formed the predominant secondary memory subset and maintained superior pathogen control. The effector-like memory subset displayed a distinct pattern of tissue distribution and localization within the spleen, and their enhanced capacity to eliminate Listeria involved specialized utilization of cytolysis. Together, these data suggest that long-lived effector CD8+ T cells are optimal for protective immunity against certain pathogens.
•Effector-like CD27lo CD8+ T cells persist into primary and secondary memory pools•Despite weak expansion, “long-lived effectors” optimally control Listeria and vaccinia•CD27lo memory CD8+ cells show tissue localization favoring rapid pathogen encounter•Cytolysis is selectively utilized by CD27lo memory cells for Listeria control |
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ISSN: | 1074-7613 1097-4180 |
DOI: | 10.1016/j.immuni.2013.05.009 |