A novel onco-miR-365 induces cutaneous squamous cell carcinoma

The expression levels of miR-365 vary in different malignancies. Herein, we found that miR-365 was overexpressed in both cells and clinical specimens of cutaneous squamous cell carcinoma (SCC). We demonstrated that the HaCaT(pre-miR-365-2) cell line, which overexpressed miR-365, could induce subcuta...

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Veröffentlicht in:Carcinogenesis (New York) 2013-07, Vol.34 (7), p.1653-1659
Hauptverfasser: Zhou, Meijuan, Liu, Weilin, Ma, Shudong, Cao, Hong, Peng, Xuebiao, Guo, Ling, Zhou, Xinhua, Zheng, Li, Guo, Linlang, Wan, Miaojian, Shi, Weimin, He, Yingjie, Lu, Chao, Jiang, Lihong, Ou, Chengshan, Guo, Yuanxia, Ding, Zhenhua
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Sprache:eng
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Zusammenfassung:The expression levels of miR-365 vary in different malignancies. Herein, we found that miR-365 was overexpressed in both cells and clinical specimens of cutaneous squamous cell carcinoma (SCC). We demonstrated that the HaCaT(pre-miR-365-2) cell line, which overexpressed miR-365, could induce subcutaneous tumors in vivo. Antagomir-365, an anti-miR-365 oligonucleotide, inhibited cutaneous tumor formation in vivo, along with G1 phase arrest and apoptosis of cancer cells. These findings suggest that miR-365 may act as an onco-miR in cutaneous SCC both in vitro and in vivo. The present study provides valuable insight into the role of miR-365 in cutaneous SCC formation, which can help develop new drug and miR-365 target-based therapies for cutaneous SCC.
ISSN:0143-3334
1460-2180
DOI:10.1093/carcin/bgt097