Vaccine design: emerging concepts and renewed optimism

Graphical abstract Highlights ► Highly variable and complex pathogens remain challenging vaccine targets. ► Systems biology and reverse vaccinology continue to foster success. ► New ways of presenting conserved, functionally critical epitopes hold promise. ► Adjuvant systems allow for enduring, nati...

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Veröffentlicht in:	Current opinion in biotechnology 2013-12, Vol.24 (6), p.1078-1088
Hauptverfasser:	Grimm, Sebastian K, Ackerman, Margaret E
Format:	Artikel
Sprache:	eng
Schlagworte:	adjuvants Adjuvants, Immunologic AIDS Vaccines - immunology Animals Antigen Presentation - immunology B-Lymphocytes - immunology Drug Delivery Systems Human immunodeficiency virus Humans immune response Immunity, Innate - immunology Immunodominant Epitopes - immunology Internal Medicine malaria Malaria Vaccines - immunology medical treatment monitoring pathogens Precision Medicine Systems Biology T-Lymphocytes - immunology vaccination vaccine development vaccines Vaccines - biosynthesis Vaccines - chemistry Vaccines - immunology
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Beschreibung
Zusammenfassung:	Graphical abstract Highlights ► Highly variable and complex pathogens remain challenging vaccine targets. ► Systems biology and reverse vaccinology continue to foster success. ► New ways of presenting conserved, functionally critical epitopes hold promise. ► Adjuvant systems allow for enduring, native antigen presentation. ► An ideal vaccine provides synergy between innate, cellular, and humoral immunity.
ISSN:	0958-1669 1879-0429
DOI:	10.1016/j.copbio.2013.02.015