BCL11A overexpression predicts survival and relapse in non-small cell lung cancer and is modulated by microRNA-30a and gene amplification

Aberrant activation of the proto-oncogene B-cell lymphoma/leukemia 11A (BCL11A) has been implicated in the pathogenesis of leukemia and lymphoma. However, the clinical significance of BCL11A in non-small cell lung cancer (NSCLC) remains unknown. We examined BCL11A expression at the protein and mRNA...

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Veröffentlicht in:	Molecular cancer 2013-06, Vol.12 (1), p.61-61, Article 61
Hauptverfasser:	Jiang, Ben-yuan, Zhang, Xu-chao, Su, Jian, Meng, Wei, Yang, Xue-ning, Yang, Jin-ji, Zhou, Qing, Chen, Zhi-yong, Chen, Zhi-hong, Xie, Zhi, Chen, Shi-liang, Wu, Yi-long
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Adult Aged Animals B-cell lymphoma Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology Carrier Proteins - genetics Carrier Proteins - metabolism Cell Line Confidence intervals DNA Copy Number Variations DNA repair Female Gene Amplification Gene Expression Gene Expression Regulation, Neoplastic Genetic aspects Histology Humans Instrument industry Leukemia Lung cancer Lung cancer, Non-small cell Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - mortality Lung Neoplasms - pathology Male Medical research Medicine, Experimental Mice MicroRNA MicroRNAs - genetics Middle Aged Mortality Multivariate analysis Neoplasm Staging Nuclear Proteins - genetics Nuclear Proteins - metabolism Physiological aspects Prognosis Proteins Proto-oncogenes Recurrence RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Science Statistical analysis Studies Survival analysis Technological change
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Zusammenfassung:	Aberrant activation of the proto-oncogene B-cell lymphoma/leukemia 11A (BCL11A) has been implicated in the pathogenesis of leukemia and lymphoma. However, the clinical significance of BCL11A in non-small cell lung cancer (NSCLC) remains unknown. We examined BCL11A expression at the protein and mRNA levels in a cohort (n=114) of NSCLC patients and assessed the relationship between BCL11A expression and clinicopathological parameters. Data from array-based Comparative Genomic Hybridization (aCGH) and microRNA transfection experiments were integrated to explore the potential mechanisms of abnormal BCL11A activation in NSCLC. Compared to adjacent non-cancerous lung tissues, BCL11A expression levels were specifically upregulated in NSCLC tissues at both the mRNA (t=9.81, P
ISSN:	1476-4598 1476-4598
DOI:	10.1186/1476-4598-12-61