The regulation and function of micrornas in kidney diseases

MicroRNAs (miRNA) are endogenous short noncoding RNAs, which regulate virtually all major cellular processes by inhibiting target gene expression. In kidneys, miRNAs have been implicated in renal development, homeostasis, and physiological functions. In addition, miRNAs play important roles in the p...

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Veröffentlicht in:	IUBMB life 2013-07, Vol.65 (7), p.602-614
Hauptverfasser:	Wei, Qingqing, Mi, Qing‐Sheng, Dong, Zheng
Format:	Artikel
Sprache:	eng
Schlagworte:	acute kidney injury Acute Kidney Injury - genetics Acute Kidney Injury - pathology allograft rejection Biomarkers chronic kidney disease diabetic nephropathy Homeostasis Humans hypertensive nephropathy kidney Kidney Diseases - classification Kidney Diseases - genetics Kidney Diseases - pathology microRNA MicroRNAs - genetics polycystic kidney disease renal cell carcinoma
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Zusammenfassung:	MicroRNAs (miRNA) are endogenous short noncoding RNAs, which regulate virtually all major cellular processes by inhibiting target gene expression. In kidneys, miRNAs have been implicated in renal development, homeostasis, and physiological functions. In addition, miRNAs play important roles in the pathogenesis of various renal diseases, including renal carcinoma, diabetic nephropathy, acute kidney injury, hypertensive nephropathy, polycystic kidney disease, and others. Furthermore, miRNAs may have great values as biomarkers in different kidney diseases. © 2013 IUBMB Life, 65(7):602–615, 2013.
ISSN:	1521-6543 1521-6551
DOI:	10.1002/iub.1174