Delayed administration of a PTEN inhibitor BPV improves functional recovery after experimental stroke

Highlights ► Delayed BPV treatment improved long-term functional recovery following MCAO. ► Delayed BPV treatment did not reduce acute infarction following MCAO. ► Delayed BPV treatment enhanced axon densities in the ischemic brain. ► BPV activated Akt/mTOR in the ischemic brain following MCAO. ► Ak...

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Veröffentlicht in:	Neuroscience 2013-02, Vol.231, p.272-281
Hauptverfasser:	Mao, L, Jia, J, Zhou, X, Xiao, Y, Wang, Y, Mao, X, Zhen, X, Guan, Y, Alkayed, N.J, Cheng, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals axonal densities Axons - drug effects Axons - metabolism Behavior, Animal - drug effects Biological and medical sciences BPV Brain - drug effects Brain - metabolism Brain - physiopathology Brain Ischemia - drug therapy Brain Ischemia - metabolism Brain Ischemia - physiopathology Disease Models, Animal Enzyme Inhibitors - pharmacology functional recovery Male Medical sciences Mice Myelin Basic Protein - metabolism Neurology Neurons - drug effects Neurons - metabolism Phosphorylation - drug effects Proto-Oncogene Proteins c-akt - metabolism PTEN inhibitor PTEN Phosphohydrolase - antagonists & inhibitors PTEN Phosphohydrolase - metabolism Recovery of Function - drug effects Recovery of Function - physiology stroke Stroke - drug therapy Stroke - metabolism Stroke - physiopathology TOR Serine-Threonine Kinases - metabolism Vanadium Compounds - pharmacology Vascular diseases and vascular malformations of the nervous system
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Zusammenfassung:	Highlights ► Delayed BPV treatment improved long-term functional recovery following MCAO. ► Delayed BPV treatment did not reduce acute infarction following MCAO. ► Delayed BPV treatment enhanced axon densities in the ischemic brain. ► BPV activated Akt/mTOR in the ischemic brain following MCAO. ► Akt/mTOR inhibition abolished BPV-enhanced axonal outgrowth following OGD in vitro.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.11.050